E1518
Echistatin from Echis carinatus
lyophilized powder, γ-irradiated, BioXtra
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About This Item
Productos recomendados
origen biológico
Echis carinatus
Nivel de calidad
esterilidad
γ-irradiated
Línea del producto
BioXtra
Ensayo
>95% (SDS-PAGE)
Formulario
lyophilized powder
mol peso
5.2-5.4 kDa
envase
pkg of 50 μg
técnicas
cell culture | mammalian: suitable
solubilidad
water: soluble 0.1 mg/mL, clear, colorless
Condiciones de envío
ambient
temp. de almacenamiento
−20°C
Clave InChI
XLBBKEHLEPNMMF-SSUNCQRMSA-N
Descripción general
Echistatin is a small peptide disintegrin that has no multiple epitopes. It is a single chain polypeptide with a molecular mass of 5400. Echistatin has eight cysteines and the sequence arginine glycine aspartic acid (RGD).
Aplicación
Echistatin from Echis carinatus has been used in diabetic rabbits grouping and treatment and murine iPSC (induced pluripotent stem cell) culture.
Acciones bioquímicas o fisiológicas
Disintegrins represent a novel family of integrin β1 and β3 inhibitor proteins isolated from viper venoms. They are low molecular-weight, cysteine-rich peptides containing the Arg-Gly-Asp (RGD) sequence. They are the most potent known inhibitors of integrin function. Disintegrins interfere with cell adhesion to the extracellular matrix, including adhesion of melanoma cells and fibroblasts to fibronectin, and are potent inhibitors of platelet aggregation.
Echistatin has the ability to prevent IRS-1 (insulin receptor substrate-1) phosphorylation induced by IGF-1 (insulin like growth factor-1). Echistatin α1, purified from the venom of the saw scaled viper, Echis carinatus has the capability to block platelet aggregation.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Los clientes también vieron
Fengbin Lin et al.
International journal of clinical and experimental pathology, 8(11), 14294-14304 (2016-01-30)
To investigate the effect of disintegrin echistatin on integrin linked kinase (ILK) and subsequent PI3-K/Akt and ERK1/2 signaling pathways in the posterior capsule opacification (PCO) model of diabetic rabbit. 56 rabbits were injected alloxan to model diabetic. Then they accepted
Animal Toxins: Facts and Protocols (2013)
Echistatin prevents posterior capsule opacification in diabetic rabbit model via integrin linked kinase signaling pathway.
Lin F, et al.
International Journal of Clinical and Experimental Pathology, 8(11), 14294-14294 (2015)
Insulin-like Growth Factor Receptor Signalling (2003)
Ozge Er et al.
Applied biochemistry and biotechnology, 187(4), 1539-1550 (2018-10-03)
Snake venoms are a natural biological source that has potential therapeutic value with various protein compounds. Disintegrins originally were discovered as a family of proteins from snake venoms composed of cysteine rich low molecular weight polypeptides. Disintegrins exhibit specific binding
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