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Merck

E0156

Sigma-Aldrich

Anti-Estrogen-Related Receptor β antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-ERRβ, Anti-NR3B2

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About This Item

Número MDL:
Código UNSPSC:
12352203

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

reactividad de especies

human

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1 μg/mL using human liver, hepatocytes

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... ESRRB(2103)
mouse ... Esrrb(26380)
rat ... Esrrb(299210)

Inmunógeno

synthetic peptide corresponding to the internal domain of human estrogen-related receptor β, conjugated to KLH. The immunizing peptide has 93% homology with the rat and mouse gene.

Aplicación

Anti-Estrogen-Related Receptor β antibody produced in rabbit was used for immunocytochemistry of neurons from mouse model of glaucoma at a working dilution of 1:500. It was also used for immunohistochemistry of mouse brain sections.

Acciones bioquímicas o fisiológicas

Estrogen-Related Receptors (ERR) are hormone receptors that bind estrogen response elements that in turn bind specific DNA sequences and regulate transcription. Three ERRs are known, alpha, beta and gamma, with highly conserved ligand and DNA binding sequences. ERRβ is selectively expressed in brain and is an important modulator of energy balance, food intake, neuropeptide levels and response to stress.

Forma física

Solution in phosphate buffered saline, containing 0.1% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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María Angeles Real et al.
Neuroscience letters, 438(1), 48-53 (2008-05-13)
Recently, a new nuclear receptor subfamily has been identified and referred to as estrogen-related receptors. This new group shares sequence similarity, target genes, co-regulatory proteins, and action sites with the estrogen receptors; however, natural estrogens are not estrogen-related receptors ligands.
Silmara de Lima et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(23), 9149-9154 (2012-05-23)
The mature optic nerve cannot regenerate when injured, leaving victims of traumatic nerve damage or diseases such as glaucoma with irreversible visual losses. Recent studies have identified ways to stimulate retinal ganglion cells to regenerate axons part-way through the optic
William A Alaynick
Mitochondrion, 8(4), 329-337 (2008-04-01)
Lipid metabolism is a continuum from emulsification and uptake of lipids in the intestine to cellular uptake and transport to compartments such as mitochondria. Whether fats are shuttled into lipid droplets in adipose tissue or oxidized in mitochondria and peroxisomes
S D Crish et al.
Neuroscience, 229, 55-70 (2012-11-20)
Failure of anterograde transport to distal targets in the brain is a common feature of neurodegenerative diseases. We have demonstrated in rodent models of glaucoma, the most common optic neuropathy, early loss of anterograde transport along the retinal ganglion cell
Francisco M Nadal-Nicolás et al.
Zoological research, 44(1), 226-248 (2023-01-04)
Univocal identification of retinal ganglion cells (RGCs) is an essential prerequisite for studying their degeneration and neuroprotection. Before the advent of phenotypic markers, RGCs were normally identified using retrograde tracing of retinorecipient areas. This is an invasive technique, and its

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