D9150

2,3-Dimethoxy-5-methyl-p-benzoquinone

apoptosis inducer

• Sinónimos: Coenzyme Q₀
• Fórmula empírica (notación de Hill): C₉H₁₀O₄
• Número de CAS: 605-94-7
• Peso molecular: 182.17
• Beilstein: 1640422
• Número CE: 210-100-8
• Número MDL: MFCD00001595
• Código UNSPSC: 12352204
• ID de la sustancia en PubChem: 24894261
• NACRES: NA.51

Propiedades

• Formulario: powder
• mp: 58-60 °C (lit.)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COC1=C(OC)C(=O)C(C)=CC1=O
• InChI: 1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3
• Clave InChI: UIXPTCZPFCVOQF-UHFFFAOYSA-N

Descripción

Descripción general

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q₀ or DMM) is present in all the cells including neural cells.[1]

Aplicación

2,3-Dimethoxy-5-methyl-p-benzoquinone has been used:

• as a tau protein fibrillization inducer to determine the regions of tau involved in the formation of paired helical filaments (PHFs)[2]
• as a component in buffer B for cytochrome oxidation assay with subsaturating light[3]
• in the RPMI-1640 medium for 2,3-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanilide (XTT) assay to quantify antifungal activity[4]

Coenzyme Q0 inhibits (via radical quenching) reactions of gamma-irradiation induced homolytic cleavage of O-glycoside bonds in polysaccharides. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. It is toxic to other cells such as insulin producing cells.

Acciones bioquímicas o fisiológicas

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q₀) interacts with tau protein and aids in the formation of filamentous structure.[1]

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves