D8065
Dephostatin
>98% (HPLC), solid
Sinónimos:
1,4-Dihydroxy-N-methyl-N-nitrosoaniline, 2-(Methylnitrosoamino)-1,4-benzenediol, 2-(N-methyl-N-nitroso)hydroquinone
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Fórmula empírica (notación de Hill):
C7H8N2O3
Número CAS:
Peso molecular:
168.15
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Servicio técnico
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>98% (HPLC)
form
solid
color
light yellow
solubility
DMSO: soluble 22 mg/mL, H2O: insoluble
shipped in
wet ice
storage temp.
−20°C
SMILES string
CN(N=O)c1cc(O)ccc1O
Gene Information
human ... PTPRCAP(5790)
Biochem/physiol Actions
CD45-associated protein tyrosine phosphatase inhibitor.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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S Wakino et al.
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The cyclin-dependent kinase inhibitor p21(Cip1) is up-regulated in response to mitogenic stimulation in various cells. PPARgamma ligands troglitazone (TRO, 10 microm) and rosiglitazone (RSG, 10 microm) attenuated the induction of p21(Cip1) protein by platelet-derived growth factor (PDGF) and insulin without
A Hiroki et al.
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Et-3,4-dephostatin, a protein-tyrosine phosphatase (PTPase) inhibitor, potentiates insulin-dependent signal transduction and shows an antidiabetic effect in mice. However, it contains a nitrosamine moiety that is often mutagenic and carcinogenic. Therefore, we previously designed and synthesized methoxime-3,4-dephostatin as a nitrosamine-free analogue