D4071

5, 15-DPP

Name: 5, 15-DPP
Brand: SIGMA

Sinónimos:

5,15-Diphenyl-21H,23H-porphine, 5,15-Diphenylporphyrin, 5,15-diphenyl-Porphine

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Fórmula empírica (notación de Hill):

C₃₂H₂₂N₄

Número CAS:

22112-89-6

Peso molecular:

462.54

NACRES:

NA.77

PubChem Substance ID:

329798793

UNSPSC Code:

12352200

MDL number:

MFCD08276335

Form:

powder

Quality level:

100

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form

powder

Quality Level

100

SMILES string

c1ccc(cc1)-c2c3ccc(cc4ccc([nH]4)c(-c5ccccc5)c6ccc(cc7ccc2[nH]7)n6)n3

InChI

1S/C32H22N4/c1-3-7-21(8-4-1)31-27-15-11-23(33-27)19-25-13-17-29(35-25)32(22-9-5-2-6-10-22)30-18-14-26(36-30)20-24-12-16-28(31)34-24/h1-20,33,36H/b23-19-,24-20-,25-19-,26-20-,31-27-,31-28-,32-29-,32-30-

InChI key

FNNOEKVUXXVPAI-DUVOQLPESA-N

Categorías relacionadas

Bioactive Small Molecule Inhibitors

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1 of 4

Este artículo	D4007	D4505	SML0117
Sigma-Aldrich D4071 5, 15-DPP	Sigma-Aldrich D4007 5,5-Diphenylhydantoin	Sigma-Aldrich D4505 5,5-Diphenylhydantoin sodium salt	Sigma-Aldrich SML0117 Fosphenytoin disodium salt hydrate
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100

Application

5, 15-DPP has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:

to analyze its effects on malignant peripheral nerve sheath tumor (MPNST) survival and proliferation[1]
to study its effects on the thymic stromal lymphopoietin (TSLP) modulation of nometastatic gene 23-H1 (NME1 or nm23-H1) expression in human trophoblasts[2]
to study its effects on 17β-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced M2 polarization in human macrophages and endometrial stromal cells[3]

Biochem/physiol Actions

5, 15-DPP is a selective STAT3 inhibitor and a selective STAT3-SH2 antagonist

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Thymic stromal lymphopoietin downregulates NME1 expression and promotes invasion in human trophoblasts via the activation of STAT3 signaling pathway.

Ying Wang et al.

Clinical immunology (Orlando, Fla.), 143(1), 88-95 (2012-03-01)

Our previous study has demonstrated that TSLP induces the invasion of human trophoblasts and plays a role in embryo implantation. The present study is undertaken to explore the mechanism by which TSLP modulates trophoblast invasion. It was revealed that TSLP

Combined 17β-Estradiol with TCDD Promotes M2 Polarization of Macrophages in the Endometriotic Milieu with Aid of the Interaction between Endometrial Stromal Cells and Macrophages.

Yun Wang et al.

PloS one, 10(5), e0125559-e0125559 (2015-05-08)

The goal of this study is to elucidate the effects of 17β-estradiol and TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) on macrophage phenotypes in the endometriotic milieu. Co-culture of endometrial stromal cells (ESCs) and U937 cells (macrophage cell line) was performed to simulate the endometriotic

ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms.

Jody Fromm Longo et al.

Cell communication and signaling : CCS, 17(1), 74-74 (2019-07-12)

We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However, MPNSTs variably express multiple erbB receptors with distinct functional characteristics and it is not clear which of these

Inhibiting the activation of MAPK (ERK1/2) in stressed Müller cells prevents photoreceptor degeneration.

Shaoxue Zeng et al.

Theranostics, 12(15), 6705-6722 (2022-10-04)

Rationale: Müller cells play an essential role in maintaining the health of retinal photoreceptors. Dysfunction of stressed Müller cells often results in photoreceptor degeneration. However, how these cells communicate under stress and the signalling pathways involved remain unclear. In this

Número de artículo de comercio global

SKU	GTIN
D4071-10MG	04061832644882
D4071-50MG	04061832644899

Preguntas

Anónimo

hace 2 años

In which solvents is 5,15 DPP dissolved?

1 respuesta
1. Technical Support
  
  hace 2 años
  
  The solubility of the product is not tested as this is not a part of the product specification.
  However, not the same product, but product #573109, under the same CAS number had a solubility: DMSO (<1 mg/ml).
  
  ¿Le ha resultado útil?

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