D3897

2′-Deoxycytidine

≥99% (HPLC)

• Sinónimos: Cytosine deoxyriboside
• Fórmula empírica (notación de Hill): C₉H₁₃N₃O₄
• Número de CAS: 951-77-9
• Peso molecular: 227.22
• Beilstein: 87567
• Número CE: 213-454-1
• Número MDL: MFCD00006547
• Código UNSPSC: 41106305
• ID de la sustancia en PubChem: 24893793
• NACRES: NA.51

Propiedades

• origen biológico: synthetic (organic)
• Análisis: ≥99% (HPLC)
• formulario: powder
• solubilidad: water: 50 mg/mL, clear, colorless to very faintly yellow
• temp. de almacenamiento: −20°C
• cadena SMILES: NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2
• InChI: 1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1
• Clave InChI: CKTSBUTUHBMZGZ-SHYZEUOFSA-N

Descripción

Descripción general

2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.

Aplicación

2′-Deoxycytidine has been used:

• as a substrate for Trypanosoma brucei cytidine deaminase (TbCDA) to measure its activity
• as a standard in the isolation and quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC–MS)
• to study the role of autophagy in response to oncogenes and DNA replication stress

Acciones bioquímicas o fisiológicas

2′-Deoxycytidine (deoxyC) forms dCTP upon phosphorylation which is used to synthesis DNA via various DNA polymerases or reverse transcriptases. DeoxyC is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2′-deoxyuridine. DeoxyC is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). DeoxyC serves as a potential head and neck cancer marker.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)