D2667
2,5-Dihydroxycinnamic acid methyl ester
≥95%, crystalline
Sinónimos:
Erbstatin analog, Methyl 2,5-dihydroxycinnamate
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Fórmula empírica (notación de Hill):
C10H10O4
Número CAS:
Peso molecular:
194.18
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
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≥95%
form
crystalline
color
yellow
mp
181-183 °C
solubility
0.1 M NaOH: soluble, H2O: insoluble, methanol: soluble
storage temp.
−20°C
SMILES string
COC(=O)\C=C\c1cc(O)ccc1O
InChI
1S/C10H10O4/c1-14-10(13)5-2-7-6-8(11)3-4-9(7)12/h2-6,11-12H,1H3/b5-2+
InChI key
BQCNSTFWSKOWMA-GORDUTHDSA-N
Biochem/physiol Actions
Inhibitor of EGF receptor-associated tyrosine kinase.
Other Notes
Stable analog of erbstatin.
Disclaimer
Photosensitive.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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R R Hartmann et al.
Melanoma research, 7 Suppl 2, S27-S33 (1997-08-01)
Differentiation therapy is an attractive option for malignant melanoma, as traditional forms of chemotherapy seem to have little effect on this type of tumour. Among the several pathways for the experimental induction of differentiation of melanoma, we have focused on
J Sandy et al.
Bone, 23(1), 17-26 (1998-07-14)
This investigation examined which signal pathways are of relevance in growth factor-stimulated bone cell mitogenesis. Platelet-derived growth factor (PDGF) and insulin-like growth factor-II (IGF-II) were potent mitogens for both the MG-63 osteoblast cell line and for primary cultures of human
O S Ruiz et al.
Regulatory peptides, 77(1-3), 155-161 (1998-11-11)
To examine the role of tyrosine kinase (TK) on basolateral membrane (BLM) transport, we looked for the presence of TK activity in these membranes and showed that the synthetic substrate for TK, poly [Glu80 Na, Tyr20] caused a three-fold increase
P Lassota et al.
The Journal of biological chemistry, 271(42), 26418-26423 (1996-10-18)
Topoisomerase II is an essential enzyme for proliferation of eukaryotic cells. It is also a target for many antineoplastic drugs that promote stabilization of covalent complexes between topoisomerase II and DNA. Topoisomerase II and protein kinases both catalyze the transfer
Z I Krutetskaia et al.
Tsitologiia, 39(2-3), 164-176 (1997-01-01)
The effect of two structurally distinct tyrosine kinase inhibitors, genistein (100 microM) and methyl-2, 5-dihydroxycinnamate (25 microM) on ATP- and thapsigargin-induced Ca2+ signals in Fura-2-loaded rat peritoneal macrophages was investigated. Both compounds were shown to inhibit ATP-evoked Ca2+ entry but
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