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D103

(±)-2,3-Dichloro-α-methylbenzylamine hydrochloride

solid

Sinónimos:

DCMB, LY-78335

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Fórmula empírica (notación de Hill):
C8H9Cl2N · HCl
Número CAS:
39226-94-3
Peso molecular:
226.53
UNSPSC Code:
12352202
PubChem Substance ID:
24278157
MDL number:
MFCD00055225
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form

solid

color

white

solubility

H2O: soluble (Solutions may be stored for 1-2 days at 4 °C.), ethanol: soluble (Solutions may be stored for 1-2 days at 4 °C.)

SMILES string

Cl[H].CC(N)c1cccc(Cl)c1Cl

Gene Information

human ... PNMT(5409)

Biochem/physiol Actions

PNMT inhibitor.

Clase de almacenamiento

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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G Engberg et al.
Brain research, 223(1), 49-58 (1981-10-26)
The functional significance of the morphologically identified adrenaline (A)-mediated input to the noradrenergic nucleus locus coeruleus (LC) was pharmacologically analyzed. By means of single unit recording techniques the LC neurons in the rat brain were studied following administration of SK&F
R W Fuller
Annual review of pharmacology and toxicology, 22, 31-55 (1982-01-01)
Neurons that contain PNMT, the epinephrine-forming enzyme, have their cell bodies in brain stem regions in rat brain and send projections mainly into other brain stem areas, hypothalamus, and spinal cord. These neurons can be affected pharmacologically by various kinds
T A Glauser et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(6), 657-669 (1993-06-01)
1. Thiol methyltransferase (TMT) is a microsomal enzyme catalyzing the S-methylation of aliphatic sulphydryl drugs and xenobiotics. Studies of the functional significance of S-methylation catalysed by TMT have been hampered by lack of a potent, relatively specific, non-toxic inhibitor of
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