C6223

Monoclonal Anti-CXCR-1 (IL-8 RA) antibody produced in mouse

clone 42705.111, purified immunoglobulin, lyophilized powder

• Número MDL: MFCD02096157
• Código UNSPSC: 51111800
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: 42705.111, monoclonal
• formulario: lyophilized powder
• reactividad de especies: human
• técnicas: flow cytometry: 10 μg/mL using using human blood cells (10 μL diluted antibody/10⁵-10⁶ cells); immunohistochemistry (frozen sections): 25 μg/mL using human tissue (speen); neutralization: suitable
• isotipo: IgG2a
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... IL8RA(3577) ; mouse ... Il8ra(227288)

Descripción

Descripción general

Chemokine receptor CXCR1 also refers as type I IL-8 receptor or IL-8RA is a class A, rhodopsin-like G-protein-coupled receptor, expressed mainly in neutrophils but not in T or B lymphocytes . It has a crucial role in cellular signal transduction and targeted as drug receptors. Monoclonal anti-CXCR-1 (IL-8 RA) antibody can be used to neutralize the bioactivity facilitated by human cell surface CXCR-1. Mouse anti-CXCR-1 (IL-8 RA) antibody reacts specifically with CXCR-1 transfected cells but not with the parent cell line. The product has also shown no cross-reactivity with human CXCR-2.

Especificidad

The antiboody, in the presence of anti-CXCR2 (Sigma Product No. C6348), will neutralize human cell surface CXCR-1 mediated-myloperoxidase release from human granulocytes induced by IL-8. The antibody reacts with human CXCR1 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR2.

Inmunógeno

human CXCR1 transfected NSO mouse myeloma cells.

Aplicación

Monoclonal anti-CXCR-1 (IL-8 RA) antibody can be used in flow cytometry for detecting CXCR-1 present on human blood cells. It can also be used in immunohistochemistry (25 μg/mL) using frozen human tissue sections (spleen).

Forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Nota de preparación

Purified using protein G.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable