C4396
Carbonic Anhydrase I from human erythrocytes
Sinónimos:
Carbonate Dehydratase, Carbonate Hydrolyase, Carbonic Anhydrase Isozyme I
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
5 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 297,00 € |
1 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 470,00 € |
25 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 1460,00 € |
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Número CAS:
UNSPSC Code:
12352204
NACRES:
NA.25
EC Number:
232-576-6
MDL number:
Specific activity:
100-500 W-A units/mg protein
297,00 €
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Servicio técnico
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Carbonic anhydrase from human erythrocytes (HCA) has been used to study the molten-globule state of carbonic anhydrase (CA). Chaperone-like α-crystallin binds to this state of the enzyme and prevents its aggregation.[1] The enzyme from sigma has been used for the analysis of thermodynamic stability of the enzyme.[2] Furthermore, its clinical significance has been evaluated in human non-small cell lung cancer.[3]
Biochem/physiol Actions
Carbonic anhydrase is a zinc metalloenzyme that has a molecular weight of approximately 30,000 Da. The enzyme catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in vital processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, this enzyme is an important target for inhibitors with clinical applications in various pathologies such as glaucoma, epilepsy and Parkinson′s disease.[2]
Preparation Note
chromatographically
purified.
purified.
Other Notes
One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0 °C. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)
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Este artículo | |||
|---|---|---|---|
| specific activity 100-500 W-A units/mg protein | specific activity - | specific activity - | specific activity ≥3,500 W-A units/mg protein |
| Gene Information human ... CA1(759) | Gene Information - | Gene Information - | Gene Information - |
| form powder | form lyophilized powder | form powder | form lyophilized powder |
| mol wt 30 kDa | mol wt ~29 kDa | mol wt ~29 kDa | mol wt - |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. - | UniProt accession no. - |
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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