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Merck

C4045

Sigma-Aldrich

Chondroitin disaccharide Δdi-4S sodium salt

≥98% (HPLC)

Sinónimos:

α-ΔUA-[1→3]-GalNAc-4S

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About This Item

Fórmula lineal:
C14H19NO14SNa2
Número de CAS:
Peso molecular:
503.34
Código UNSPSC:
12352201
ID de la sustancia en PubChem:
NACRES:
NA.25

Análisis

≥98% (HPLC)

formulario

powder

técnicas

HPLC: suitable

color

white

solubilidad

H2O: soluble 10 mg/mL, clear, colorless

temp. de almacenamiento

−20°C

cadena SMILES

[Na+].[Na+].CC(=O)N[C@@H](C=O)[C@@H](O[C@@H]1OC(=C[C@H](O)[C@H]1O)C([O-])=O)[C@@H](OS([O-])(=O)=O)[C@H](O)CO

InChI

1S/C14H21NO14S.2Na/c1-5(18)15-6(3-16)11(12(8(20)4-17)29-30(24,25)26)28-14-10(21)7(19)2-9(27-14)13(22)23;;/h2-3,6-8,10-12,14,17,19-21H,4H2,1H3,(H,15,18)(H,22,23)(H,24,25,26);;/q;2*+1/p-2/t6-,7-,8+,10+,11+,12-,14-;;/m0../s1

Clave InChI

DFRMXDKXNRVAFE-WBOKVGFFSA-L

Descripción general

Chondroitin, a glucosaminoglycan (GAG), is a polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA) that can be sulfated on the either or both GalNAc and GlcA units. Chondroitin and its sulfates are frequently attached to proteins to form proteoglycans.

Aplicación

Chondroitin disaccharide Δdi-4S may be used as a substrate for the identification and characterization of enzymes such as Clostridium perfringens unsaturated glucuronyl hydrolase. Chondroitin disaccharide Δdi-4S may be used as a reference compound in the analysis of chondroitin disaccharide sulfates.

Otras notas

ΔUA = 4-deoxy-L-threo-hex-4-enopyranosyluronic acid; GalNAc = N-acetyl-D-galactosamine; 4S = 4-sulfate
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

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Chondroitin sulfate: A key molecule in the brain matrix.
Kwok JC, Warren P, Fawcett JW.
The International Journal of Biochemistry & Cell Biology, 44(4), 582-586 (2011)
Yusuke Nakamichi et al.
The Journal of biological chemistry, 286(8), 6262-6271 (2010-12-15)
Pathogenic Streptococcus agalactiae produces polysaccharide lyases and unsaturated glucuronyl hydrolase (UGL), which are prerequisite for complete degradation of mammalian extracellular matrices, including glycosaminoglycans such as chondroitin and hyaluronan. Unlike the Bacillus enzyme, streptococcal UGLs prefer sulfated glycosaminoglycans. Here, we show
Glucosamine and chondroitin sulfate.
Miller KL, Clegg DO.
Rheumatic Diseases Clinics of North America, 23(1), 103-118 (2011)
Yulin Li et al.
Chemical Society reviews, 41(6), 2193-2221 (2011-11-26)
Injectable hydrogels with biodegradability have in situ formability which in vitro/in vivo allows an effective and homogeneous encapsulation of drugs/cells, and convenient in vivo surgical operation in a minimally invasive way, causing smaller scar size and less pain for patients.
Juliane Salbach et al.
Journal of molecular medicine (Berlin, Germany), 90(6), 625-635 (2011-12-22)
To meet the growing need for tissue replacement materials for our aging population, the development of new adaptive biomaterials is essential. The tissues with the highest demand for implant materials are skin and bone. These tissues share various similarities, including

Artículos

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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