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C3788

Sigma-Aldrich

Chondroitin sulfate B sodium salt

from Porcine intestinal mucosa, ≥90%, lyophilized powder

Sinónimos:

β-Heparin, Dermatan sulfate sodium salt

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About This Item

Número de CAS:
54328-33-5
Número MDL:
MFCD00151683
Código UNSPSC:
12352201
NACRES:
NA.25

origen biológico

Porcine intestinal mucosa

Análisis

≥90%

formulario

lyophilized powder

impurezas

≤20% water (Karl Fischer)

color

white

solubilidad

H2O: 5 mg/mL, clear, colorless

trazas de catión

Na: 7.0-11.5%

temp. de almacenamiento

2-8°C

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Descripción general

Chondroitin, a glucosaminoglycan (GAG), is a polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA) that can be sulfated on the either or both GalNAc and GlcA units. Chondroitin and its sulfates are frequently attached to proteins to form proteoglycans. Chondroitin sulfate B (Dermatam sulfate) is a component of proteoglycans such as decorin, biglycan and versican. Chondroitin sulfate B is used to study β peptide (1-42) cytotoxicity.

Aplicación

Chondroitin sulfate B may be used to study its roles as a biomolecule receptor, mediator of cell signaling and cell binding molecule. It may be used to compare its properties to those of chondroitin sulfate A and chondroitin sulfate C. Chondroitin sulfate B is used to study β peptide(1-42) cytotoxicity.

Acciones bioquímicas o fisiológicas

As a large, negatively charged, hydrophilic molecule that is too inflexible to fold into a compact globular structure, chondroitin sulfate molecules form porous hydrated gels, providing mechanical support to tissue and allowing rapid diffusion of water-soluble molecules and migration of cells.

Componentes

Chondroitin Sulfate B is an acidic mucopolysaccharide found in cartilage, skin, cornea, and umbilical cord. It is composed of alternating N-acetylgalactosamine, L-iduronic acid, and sulfate residues in equimolar quantities where carbon 4 of the N-acetylgalactosamines is sulfated.

Precaución

Store this product at 2-8°C.

Nota de preparación

This product is soluble in water at 100 mg/mL.

Otras notas

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sylvia Gruber et al.
International journal of molecular sciences, 19(6) (2018-06-09)
Oral mucositis is the most frequently occurring early side effect of head-and-neck cancer radiotherapy. Systemic dermatan sulfate (DS) treatment revealed a significant radioprotective potential in a preclinical model of oral mucositis. This study was initiated to elucidate the mechanistic effects
Rebecca Morgan et al.
The Journal of rheumatology, 31(8), 1497-1505 (2004-08-04)
Pristane induced arthritis (PIA) is a seropositive experimental murine model that closely resembles rheumatoid arthritis (RA). Immune reactivity to a broad spectrum of autoantigens has been recognized in this disease model. We investigated the specificity of the autoimmune response in
Sylvia Gruber et al.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 194(7), 675-685 (2018-03-03)
Oral mucositis is a frequent, dose-limiting side effect of radio(chemo)therapy of head-and-neck malignancies. The epithelial radiation response is based on multiple tissue changes, which could offer targets for a biologically tailored treatment. The potential of dermatan sulfate (DS) to modulate radiation-induced oral
Cheng Zhang et al.
Connective tissue research, 61(5), 475-484 (2019-05-29)
Recent data suggest that there is a lack of turnover in the core of human tendon, but it remains unknown whether there are regional differences between core and periphery of the cross section. The purpose of this project was to
Ana M Saraiva et al.
Macromolecular bioscience, 10(10), 1152-1163 (2010-05-19)
The amyloid-β peptide (Aβ) plays a central role in the mechanism of Alzheimer's disease, being the main constituent of the plaque deposits found in AD brains. Aβ amyloid formation and deposition are due to a conformational switching to a β-enriched
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Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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