C3660
Complement C9 from human serum
≥150,000 C9H50 units/mg (using C9 deficient serum)
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
0.1 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 318,00 € |
Acerca de este artículo
Form:
solution
Assay:
≥85% (SDS-GE)
Biological source:
human
318,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Complement C9 from human serum is an essential part of the terminal complement system. It has been a topic in cancer research, where extracellular phosphorylation by ecto-PK of K562 cells on serine residues may serve as a protective mechanism against complement in tumor cells. Additionally, it can be used as a biomarker (in fucosylated form) for squamous cell lung cancer, as patients tend to show elevated levels of C9 protein.
Biochem/physiol Actions
Complement component C9 is the final component of the membrane attack complex (MAC) responsible for cell lysis by complement. CD59 binds to both C8 and C9 and prevents assembly of an active MAC, protecting cells against lytic activity.[1]
Physical form
Supplied as a solution in phosphate buffered saline, pH 7.2.
Analysis Note
Functionally pure by a sensitive hemolytic assay using deficient sera.
Other Notes
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Este artículo | |||
|---|---|---|---|
| biological source human | biological source human serum | biological source human serum | biological source human serum |
| assay ≥85% (SDS-GE) | assay ≥85% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay - |
| form solution | form solution | form solution | form solution |
| Gene Information human ... C9(735) | Gene Information human ... C7(730) | Gene Information human ... C5(727) | Gene Information human ... C4A(720) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
Clase de almacenamiento
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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