C3242

CDKi hydrochloride

≥98% (HPLC), solid

• Sinónimos: 2,4-Diamino-5-oxo-pyrimidine hydrochloride
• Fórmula empírica (notación de Hill): C₄H₆N₄O · xHCl
• Número CAS: 70035-83-5
• Peso molecular: 126.12 (free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724437
• MDL number: MFCD08277042

Propiedades

• assay: ≥98% (HPLC)
• form: solid
• solubility: H₂O: 21 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl[H].Nc1ncc(O)c(N)n1
• InChI: 1S/C4H6N4O.ClH/c5-3-2(9)1-7-4(6)8-3;/h1,9H,(H4,5,6,7,8);1H
• InChI key: KEFSYBXFZWLDQU-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

CDKi hydrochloride is a potent and selective ATP competitiive inhibitor of cycB-CDK1, cycE-CDK2, and cycD1-CDK4. Demonstrates significant inhibitory activity against a variety of tumor type both in vitro and in vivo.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves