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C0609

Sigma-Aldrich

Carnosic acid from Rosmarinus officinalis

≥91%, powder

Sinónimos:

(4AR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid

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About This Item

Fórmula empírica (notación de Hill):
C20H28O4
Número de CAS:
3650-09-7
Peso molecular:
332.43
Número MDL:
MFCD02259459
Código UNSPSC:
12352106
ID de la sustancia en PubChem:
329774804
NACRES:
NA.25

Nivel de calidad

200

Análisis

≥91%

formulario

powder

color

faintly yellow to dark yellow

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

cadena SMILES

CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C(O)=O)c2c(O)c1O

InChI

1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1

Clave InChI

QRYRORQUOLYVBU-VBKZILBWSA-N

Aplicación

Carnosic acid from Rosmarinus officinalis is used to study its mechanisms as an antioxidant that protects lipids from peroxidation and proteins from carbonylation. Carnosic acid is used to assess its neuroprotective activies including its ability to modulate the neurotoxic effects of 6-hydroxydopamine (6-OHDA). Carnosic acid may also be used to study it anticancer potential.
Phenolic compound that is naturally occurring with antioxidant properties. Inhibits lipid peroxidation which is caused by NADH or NADPH oxidation.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Tayebeh Rezaie et al.
Investigative ophthalmology & visual science, 53(12), 7847-7854 (2012-10-20)
The herb rosemary has been reported to have antioxidant and anti-inflammatory activity. We have previously shown that carnosic acid (CA), present in rosemary extract, crosses the blood-brain barrier to exert neuroprotective effects by upregulating endogenous antioxidant enzymes via the Nrf2
A I Kuzmenko et al.
Journal of photochemistry and photobiology. B, Biology, 48(1), 63-67 (1999-04-17)
Lipid free-radical oxidation has been studied in vivo in the mitochondrial fractions of the liver of rats fed RoseOx (carnosic acid nutritional supplement) by measuring chemiluminescence. The kinetics of the lipid chemiluminescence in rats fed RoseOx are significantly different from
Mariano Walter Pertino et al.
Journal of natural products, 73(4), 639-643 (2010-04-03)
Carnosic acid (1) has been shown to possess gastroprotective activity in vitro and in vivo. However, little is known of the gastroprotective effect or cytotoxicity of carnosic acid gamma-lactone (3). To determine structure-activity relationships, a series of 17 esters of
Riham Salah El Dine et al.
Journal of natural products, 72(11), 2019-2023 (2009-10-10)
A new farnesyl hydroquinone, ganomycin I (1), was isolated along with ganomycin B (2) from the chloroform extract of the fruiting bodies of the Vietnamese mushroom Ganoderma colossum. These compounds inhibited HIV-1 protease with IC50 values of 7.5 and 1.0
Linda Saxe Einbond et al.
Fitoterapia, 83(7), 1160-1168 (2012-07-26)
Studies indicate that extracts and purified components, including carnosic acid, from the herb rosemary display significant growth inhibitory activity on a variety of cancers. This paper examines the ability of rosemary/carnosic acid to inhibit the growth of human breast cancer
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