B2515

L-Buthionine-sulfoximine

≥97% (TLC)

• Sinónimos: L-BSO
• Fórmula empírica (notación de Hill): C₈H₁₈N₂O₃S
• Número de CAS: 83730-53-4
• Peso molecular: 222.31
• Beilstein: 2367136
• Número MDL: MFCD00067000
• Código UNSPSC: 12352202
• ID de la sustancia en PubChem: 24278263
• NACRES: NA.77

Propiedades

• origen biológico: synthetic (organic)
• Análisis: ≥97% (TLC)
• formulario: powder
• mp: 224-226 °C
• solubilidad: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• cadena SMILES: CCCCS(=N)(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
• Clave InChI: KJQFBVYMGADDTQ-CVSPRKDYSA-N
• Información sobre el gen: human ... GCLC(2729) , GCLM(2730)

Descripción

Aplicación

L-Buthionine-sulfoximine has been used:

• as a selective activator for the induction of ferroptosis in rat apoptotic cells
• as an inhibitor of γ-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barley
• as a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1β expression in murine alveolar macrophages

Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

Acciones bioquímicas o fisiológicas

Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)