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AV53850

Sigma-Aldrich

Anti-ZC3H14 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Anti-FLJ11806, Anti-MGC26892, Anti-NY-REN-37, Anti-UKp68, Anti-Zinc finger CCCH-type containing 14

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

mol peso

35 kDa

reactividad de especies

human

concentración

0.5 mg - 1 mg/mL

técnicas

immunohistochemistry: suitable
western blot: suitable

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... ZC3H14(79882)

Inmunógeno

Synthetic peptide directed towards the N terminal region of human ZC3H14

Aplicación

Anti-ZC3H14 antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

Acciones bioquímicas o fisiológicas

ZC3H14 gene encodes a ubiquitously expressed evolutionarily conserved Cys(3)His zinc finger protein that belongs to poly(A)-binding protein family. The encoded protein plays an evolutionarily conserved role in regulating the poly(A) tail length in neurons.Poly(A)-binding proteins also impacts the gene expression by controlling mRNA stability, nuclear export, and translation.Mutation in ZC3H14 gene leads to brain disorder occur due to disrupted normal development and impairs neural function in humans and drosophila.

Secuencia

Synthetic peptide located within the following region: KFPSPPLPIFLPPEPVDLGSITSSSCSLNELDNISHLLRKISADINEIKG

Forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Seth M Kelly et al.
RNA (New York, N.Y.), 20(5), 681-688 (2014-03-29)
The ZC3H14 gene, which encodes a ubiquitously expressed, evolutionarily conserved, nuclear, zinc finger polyadenosine RNA-binding protein, was recently linked to autosomal recessive, nonsyndromic intellectual disability. Although studies have been carried out to examine the function of putative orthologs of ZC3H14
Sara W Leung et al.
Gene, 439(1-2), 71-78 (2009-03-24)
The human ZC3H14 gene encodes an evolutionarily conserved Cys(3)His zinc finger protein that binds specifically to polyadenosine RNA and is thus postulated to modulate post-transcriptional gene expression. Expressed sequence tag (EST) data predicts multiple splice variants of both human and
Changhui Pak et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(30), 12390-12395 (2011-07-08)
Here we report a human intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein. We identify ZC3H14 mRNA transcripts in the human central nervous system, and we

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