AV32557

Anti-GFI1 (AB2) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-Growth factor independent 1 transcription repressor, Anti-ZNF163
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• conjugado: unconjugated
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: 45 kDa
• reactividad de especies: pig, bovine, rat, human
• concentración: 0.5 mg - 1 mg/mL
• técnicas: western blot: suitable
• Nº de acceso NCBI: NP_001120687
• Nº de acceso UniProt: Q99684
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... GFI1(2672)

Descripción

Descripción general

Gfi-1 is a zinc finger repressor that inhibits the proliferation and conserves functional integrity of hematopoietic stem cells. Human GFI1 mutations have been linked to neutropenia.
Rabbit Anti-GFI1 (AB1) antibody recognizes human, mouse, rat, and canine GFI1.

Inmunógeno

Synthetic peptide directed towards the N terminal region of human GFI1

Aplicación

Rabbit Anti-GFI1 (AB2) antibody can be used for western blot applications at a concentration of 1μg/ml.

Acciones bioquímicas o fisiológicas

GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

Secuencia

Synthetic peptide located within the following region: VPAPSRADSTSNAGGAKAEPRDRLSPESQLTEAPDRASASPDSCEGSVCE

Forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable