AC-0334A

HNF4 alpha P1 (EP366) Rabbit Monoclonal Primary Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 500
• forma del anticuerpo: Ig fraction of antiserum
• clon: monoclonal
• descripción: For In Vitro Diagnostic Use in Select Regions (See Chart)
• formulario: buffered aqueous solution
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:60
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• visualización: nuclear

Descripción

Descripción general

Hepatocyte nuclear factor-4α (HNF4α) is a member of the nuclear receptor superfamily is critical for the maintenance of epithelial cell function and normal colon physiology. Isoforms of HNF4α are generated by alternative splicing of the P1 and P2 promoter. Isoforms of HNF4α 1-6 originate from P1 promoter while HNF4α 7-12 are derived from the P2 promoter. The P1 and P2 proteins differ in approximately 16-29 amino acids in the N-terminal domain. HNF4α is critical for the balance between proliferation and differentiation. In normal tissues, HNF4α P1 is localized to the nucleus and expressed in the small intestine, colon, liver, and kidney, but no expression was found in stomach and lung. HNF4α P1 may be used to identify metastatic tumors to the lung. In gastric carcinomas, intestinal, mixed and null types showed HNF4α P1 positive, but the gastric type was HNF4α P1 negative. In contrast, HNF4α P2 was expressed in all gastric carcinomas. HNF4α P1 antibody may be useful for subclassification of gastric tumors. In several studies focusing on colorectal carcinoma, HNF4α P1 was shown to be frequently lost in tumor cells. In contrast, HNF4α P2 expression was unaffected.

Calidad

IVD

IVD

IVD

RUO

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &lt0.1% Sodium Azide

Otras notas

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Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable