A9102

AH13205

≥98% (HPLC), oil

• Sinónimos: trans-2-(4-(1-Hydroxyhexyl)phenyl-5-oxocyclopentaneheptanoic acid
• Fórmula empírica (notación de Hill): C₂₄H₃₆O₄
• Número de CAS: 148436-63-9
• Peso molecular: 388.54
• Número MDL: MFCD00797641
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329771031
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: oil
• color: pale yellow
• solubilidad: DMSO: >10 mg/mL
• emisor: GlaxoSmithKline
• temp. de almacenamiento: −20°C
• cadena SMILES: CCCCCC(O)c1ccc(cc1)[C@H]2CCC(=O)[C@@H]2CCCCCCC(O)=O
• InChI: 1S/C24H36O4/c1-2-3-6-10-22(25)19-14-12-18(13-15-19)20-16-17-23(26)21(20)9-7-4-5-8-11-24(27)28/h12-15,20-22,25H,2-11,16-17H2,1H3,(H,27,28)/t20-,21-,22?/m1/s1
• Clave InChI: XMQKDOCUWFCMEJ-JAZPPYFYSA-N

Descripción

Descripción general

AH13205 is EP₂ prostanoid receptor agonist. There are five types of prostanoid receptors, which are classified based on sensitivity to the five naturally-occuring prostanoid ligand. The EP type of receptor is further divided into four subgroups – EP₁, EP₂, EP₃ and EP₄. EP₂ activation results in vascular, bronchial and reproductive smooth muscle relaxation.

Acciones bioquímicas o fisiológicas

AH13205 is a selective, low potency agonist for the EP₂ receptor. AH13205 has been shown to compete with Prostaglandin E2 (PGE2) for binding, resulting in the displacement of PGE2 binding.

Características y beneficios

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)