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A7981

Sigma-Aldrich

Anti-Aromatase antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-ARO, Anti-CYP XIX, Anti-CYP19A1 (Cytochrome P450, Family 19, Subfamily A, Polypeptide 1), Anti-Estrogen Synthase, Anti-P-450 Aromatase

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About This Item

Código UNSPSC:
12352203

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

mol peso

antigen 50-55 kDa

reactividad de especies

human

concentración

~1.0 mg/mL

técnicas

indirect immunofluorescence: 0.5-1 μg/mL using paraformaldehyde fixed HEK-293T cells transfected with Aromatase
western blot: 0.5-1 μg/mL using human placenta tissue lysate

Nº de acceso UniProt

P11511

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... CYP19A1(1588)

Descripción general

The enzyme aromatase is a member of P450 cytochrome family. Aromatase catalyzes three oxidation reactions of androstenedione A that lead to aromatization of androgens and subsequent synthesis of estrogen. The enzymatic complex of aromatase is a heterocomplex of cytochrome 450 aromatase and NADPH cytochrome P450 reductase. The tissues that produce aromatase are placenta, ovary, brain, bone, adipose tissue, skin and testis. The aromatase enzyme complex is present in the smooth endoplasmic reticulum of cells of these tissues. High levels of aromatase and estrogen are produced by the breast cancer cells. Selective aromatase inhibitors are developed to control the recurrence and survival of hormone-dependent breast cancer tissue
Anti-Aromatase specifically recognizes human aromatase (50-55 kDa).

Aplicación

Anti-Aromatase may be used for immunoblotting at a working concentration of 0.5-1 μg/ml using lysate of human placenta tissue. The antibody has also been used for immunoblotting using whole extracts or nuclear extracts of human primary trophoblasts. For immunofluorescence, a working concentration of 0.5-1 μg/ml is recommended.

Descripción de destino

Aromatase is part of the cytochrome p450 family of monooxygenases. It is involved in the production of estrogen and found localized to the endoplasmic reticulum of multiple cell types.

Forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análisis (COA)

Lot/Batch Number
020M4821
028K4776

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E A McDonald et al.
Endocrinology, 150(9), 4358-4365 (2009-06-13)
The hormone adiponectin has been shown to be important in maintaining insulin sensitivity throughout the body, whereas potential effects on the placenta have not been assessed. Pregnancy constitutes a unique physiological environment in which metabolism has a profound effect on
Jieyun Li et al.
Journal of animal science and biotechnology, 7, 57-57 (2016-10-07)
Heat stress is known to alter follicular dynamics and granulosa cell function and may contribute to the diminished reproductive efficiency commonly observed in mammals during the summer. Although several investigators have studied heat-induced ovarian injury, few reports have focused on
Ewa Monika Drzewiecka et al.
International journal of molecular sciences, 22(6) (2021-04-04)
An electromagnetic field (EMF) may affect the functions of uterine tissues. This study hypothesized that EMF changes the estrogenic activity of pig myometrium during the peri-implantation period. Tissue was collected on days 15-16 of the gestation and incubated in the
Saranya Chumsri et al.
The Journal of steroid biochemistry and molecular biology, 125(1-2), 13-22 (2011-02-22)
Estrogens are known to be important in the growth of breast cancers in both pre and postmenopausal women. As the number of breast cancer patients increases with age, the majority of breast cancer patients are postmenopausal women. Although estrogens are
Serge Carreau et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 365(1546), 1571-1579 (2010-04-21)
In most mammalian species aromatase is encoded by a single gene (Cyp19), which contains 18 exons, nine of them being translated. In man, the presence of a biologically active aromatase and oestrogen receptors (ERalpha and ERbeta) has been reported in
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