A270
Anti-α1 Adrenergic Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-ADRA1, Anti-ALPHA1BAR
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About This Item
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
buffered aqueous solution
mol peso
antigen ~60 kDa
reactividad de especies
mouse, human, rat
técnicas
indirect immunofluorescence: 1:1,000 using mouse kidney distal tubule cells
western blot: 1:400
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)
mouse ... Adra1d(11550)
rat ... Adra1d(29413)
Descripción general
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three α1AR subtypes (α1A/D, α1B, and α1C), three α2ARs (α2A, α2B, and α2C), and three βAR subtypes (β1, β2, and β3). Adrenergic receptors participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
Adrenergic receptors are a G-protien coupled receptors that exist in two forms, α or β. Ligands for adrenergic receptors are catecholamines that induce a sympathetic response in animal cells.
Rabbit polyclonal Anti-α1 Adrenergic Receptor antibody is human α1 adrenergic receptor subtype-specific and cross-reacts with rat and mouse α1 adrenergic receptor in immunoblotting. It detects α1 adrenergic receptor in mouse kidney membrane preparations by immunoblotting and stains plasma membrane of mouse kidney distal tubule cells in immunofluorescence.
Inmunógeno
A270 is produced by immunizing New Zealand white rabbits with a synthetic peptide corresponding to aa residues 339-349 of human alpha 1a adrenergic receptor. This sequence is 100% conserved within the 3rd intracellular loop of all alpha1 adrenergic receptors. Peptide sequence: K339-F-S-R-E-K-K-A-A-K-T349
Aplicación
Rabbit polyclonal Anti-α1 Adrenergic Receptor antibody is used for the localization and detection of the α1 adrenergic receptor (~ 60 kDa). It can be used in immunoblotting and immunofluorescence techniques.
Forma física
Solution in phosphate buffered saline containing 1 mg/ml BSA and 0.05% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Neuroscience, 281, 99-109 (2014-10-01)
In certain forms of nerve injury and inflammation, noradrenaline augments pain via actions on up-regulated α1-adrenoceptors (α1-ARs). The aim of this study was to use immunohistochemistry to examine α1-AR expression on peripheral neurons, cutaneous blood vessels and keratinocytes after distal
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After peripheral nerve injury, nociceptive afferents acquire an abnormal excitability to adrenergic agents, possibly due to an enhanced expression of α1-adrenoceptors (α1-ARs) on these nerve fibres. To investigate this in the present study, changes in α1-AR expression on nerve fibres
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The α1 -adrenoceptor agonist, phenylephrine, is used at high concentrations as a mydriatic agent and for the treatment of nasal congestion. Among its adverse side-effects transient burning sensations are reported indicating activation of the trigeminal nociceptive system. Neuropeptide release, calcium
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