A1354
APRIL human
recombinant, expressed in NSO cells, >95% (SDS-PAGE), lyophilized powder
Sinónimos:
A Proliferation-inducing Ligand, TALL-2, TNFSF13, TRDL-1
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About This Item
Número MDL:
Código UNSPSC:
12352200
recombinante
expressed in NSO cells
Ensayo
>95% (SDS-PAGE)
Formulario
lyophilized powder
mol peso
23-25 kDa by SDS-PAGE (reducing)
calculated mol wt 18.6 kDa
impurezas
endotoxin, tested
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... TNFSF13(8741)
Forma física
Lyophilized from a 0.2 μm filtered solution in PBS and 0.5 M NaCl, containing 50 μg BSA per 1 μg cytokine
Nota de análisis
The biological activity is measured by its ability to induce proliferation of anti-IgM-stimulated human B cells. Alternatively, the activity can be measured by its ability to bind immobilized rhBCMA/Fc.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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K Kelly et al.
Cancer research, 60(4), 1021-1027 (2000-03-08)
We have examined the activity of a new member of the tumor necrosis factor (TNF) family identified through Expressed Sequence Tag database searching using TNFalpha protein as the search query. We have termed this protein TNF-related death ligand-la (TRDL-1alpha). Traditional
P A Moore et al.
Science (New York, N.Y.), 285(5425), 260-263 (1999-07-10)
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS
M Hahne et al.
The Journal of experimental medicine, 188(6), 1185-1190 (1998-09-22)
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are
J A Gross et al.
Nature, 404(6781), 995-999 (2000-05-09)
B cells are important in the development of autoimmune disorders by mechanisms involving dysregulated polyclonal B-cell activation, production of pathogenic antibodies, and co-stimulation of autoreactive T cells. zTNF4 (BLyS, BAFF, TALL-1, THANK) is a member of the tumour necrosis factor
P Schneider et al.
The Journal of experimental medicine, 189(11), 1747-1756 (1999-06-08)
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF
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