A1260

Amantadine hydrochloride

≥98% (TLC), powder, NMDA receptor antagonist

• Sinónimos: 1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, NSC 83653, Tricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride
• Fórmula empírica (notación de Hill): C₁₀H₁₇N · HCl
• Número de CAS: 665-66-7
• Peso molecular: 187.71
• Beilstein: 4198854
• Número CE: 211-560-2
• Número MDL: MFCD00074723
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277882
• NACRES: NA.77

Propiedades

• product name: Amantadine hydrochloride,
• formulario: powder
• solubilidad: H₂O: 50 mg/mL; ethanol: soluble
• emisor: Endo
• cadena SMILES: Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
• InChI: 1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
• Clave InChI: WOLHOYHSEKDWQH-SOVZANNPSA-N

Descripción

Descripción general

Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.

Aplicación

Amantadine hydrochloride has been used:

• to determine its effectiveness in reducing surgery-induced cognitive impairment
• to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway
• to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory
• to preincubate primary cultured rat dental pulp stem cells (rDPSCs)
• to determine the pathway of internalization

Acciones bioquímicas o fisiológicas

Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.

Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P301 + P312 + P330
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves