A111050

DMT-dA(bz) Phosphoramidite

configured for ÄKTA^® and OligoPilot^®

• Sinónimos: N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
• Fórmula empírica (notación de Hill): C₄₇H₅₂N₇O₇P
• Número de CAS: 98796-53-3
• Peso molecular: 857.93
• Número MDL: MFCD00036314
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329770663
• NACRES: NA.51

Propiedades

• origen biológico: non-animal source (no BSE/TSE risk)
• tpo: for DNA synthesis
• Línea del producto: Proligo Reagents
• Análisis: ≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
• formulario: powder or granules
• técnicas: oligo synthesis: suitable
• impurezas: ≤0.3 wt. % water content (Karl Fischer)
• color: white to off-white
• λ: conforms (UV/VIS Identity)
• compatibilidad: configured for ÄKTA^® and OligoPilot^®
• perfil del nucleósido: base: deoxyadenosine; base protecting group: benzoyl; 2' protecting group: none; 5' protecting group: DMT; deprotection: standard
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
• InChI: 1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-27-13-26-48)61-40-28-42(53-31-51-43-44(49-30-50-45(43)53)52-46(55)34-14-9-7-10-15-34)60-41(40)29-58-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30-33,40-42H,13,27-29H2,1-6H3,(H,49,50,52,55)/t40-,41+,42+,62?/m0/s1
• Clave InChI: GGDNKEQZFSTIMJ-AKWFTNRHSA-N

Descripción

Descripción general

Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. Exocyclic amine functions are protected by a benzoyl group (dA(bz) and dC(bz)) or isobutyryl group (dG(ib)).Key features of DNA phosphoramidite :

• Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
• The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides. The product belongs to ABI Synthesizers synthesizers.

Información legal

OligoPilot is a registered trademark of Cytiva

ÄKTA is a registered trademark of Cytiva

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable