68795
Hydrophobin SC3
≥98% (SDS-GE)
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About This Item
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Análisis
≥98% (SDS-GE)
formulario
solid
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
Schizophyllum commune H4-8 ... SC3(9592530)
Descripción general
Hydrophobin SC3 is a class I hydrophobin of Schizophyllum commune. It is an oligomeric amphiphilic protein, rich in β-sheet. The mature protein consists of four disulfide bridges comprising eight cysteine residues. The N-terminal contains mannose residues in combination with threonine residues.
Aplicación
Hydrophobin SC3 has been used to coat nitric oxide (NO) releasing medical-grade polymer to establish an antifouling layer to work synergistically with NO′s bactericidal and antiplatelet activity (SC3-NO).
Acciones bioquímicas o fisiológicas
Hydrophobins are key regulators of fungal growth and development. The hydrophobin SC3 is known for its ability to assemble at the water and air, water and oil, and water and a hydrophobic solid interface. The self-assembling process subjects hydrophobin SC3 to many conformational changes. It permits the growth of aerial hyphae and fruiting bodies on fungi as a result of assembling at the water-air interface. Hydrophobin SC3 mediates the linking of cell wall glucans to chitin and helps in the hyphal cell wall formation. Hydrophobin SC3 might have antitumor actions and be useful in chemotherapy and radiation.
Otras notas
Currently available only in Europe.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
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Biophysical journal, 88(5), 3434-3443 (2005-03-08)
Hydrophobins are a class of small proteins that fulfill a wide spectrum of functions in fungal growth and development. They do so by self-assembling into an amphipathic membrane at hydrophilic-hydrophobic interfaces. The SC3 hydrophobin of Schizophyllum commune is the best-studied
Applied microbiology and biotechnology, 97(10), 4385-4392 (2012-08-01)
The use of mushroom extracts has been common practice in traditional medicine for centuries, including the treatment of cancer. Proteins called hydrophobins are very abundant in mushrooms. Here, it was examined whether they have antitumor activity. Hydrophobin SC3 of Schizophyllum
Biomaterials science, 7(8), 3438-3449 (2019-07-04)
In medical device design, there is a vital need for a coating that promotes treatment of the patient and simultaneously prevents fouling by biomacromolecules which in turn can progress to infections, thrombosis, and other device-related complications. In this work, hydrophobin
Journal of leukocyte biology, 102(2), 475-486 (2017-05-28)
Epigenetic changes in chromatin structure have been recently associated with the deregulated expression of critical genes in normal and malignant processes. HDAC11, the newest member of the HDAC family of enzymes, functions as a negative regulator of IL-10 expression in
ACS nano, 12(11), 11610-11624 (2018-10-20)
Hydrophilic surface chemistries can strongly bind water to produce surfaces that are highly resistant to protein adsorption and fouling. The interfacial bound water and its distinct properties have intrigued researchers for decades, yet the relationship between the water three-dimensional structure
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