51060

Guanosine 5′-diphosphate disodium salt

≥90% (HPLC)

• Sinónimos: 5′-GDP-Na₂
• Fórmula empírica (notación de Hill): C₁₀H₁₃N₅Na₂O₁₁P₂
• Número de CAS: 7415-69-2
• Peso molecular: 487.16
• Número CE: 231-026-2
• Número MDL: MFCD00084665
• Código UNSPSC: 41106305
• ID de la sustancia en PubChem: 57651304
• NACRES: NA.51

Propiedades

• origen biológico: Porcine brain; microbial (Corynebacterium sp); synthetic
• Análisis: ≥90% (HPLC)
• formulario: powder
• solubilidad: H₂O: 50 mg/mL, clear, colorless
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: [Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
• Clave InChI: LTZCGDIGAHOTKN-LGVAUZIVSA-L

Descripción

Descripción general

Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.

Aplicación

Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.

Guanosine 5′-diphosphate disodium salt has been used:

• in fluorescent metal nanoclusters selectivity of guanosine 3′-diphosphate-5′-di(tri)phosphate, ppGpp
• in screening of fluorescence emission of hypocrellin A-zinc complex
• as a component of assay buffers in the autoradiography of mice brain sections

Acciones bioquímicas o fisiológicas

Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)