vial of 0.1 mL concentrate (478M-94), vial of 0.1 mL concentrate Research Use Only (478M-94-RUO), vial of 0.5 mL concentrate (478M-95), vial of 1.0 mL concentrate (478M-96), vial of 1.0 mL concentrate Research Use Only (478M-96-RUO), vial of 1.0 mL pre-dilute Research Use Only (478M-97-RUO), vial of 1.0 mL pre-dilute ready-to-use (478M-97), vial of 7.0 mL pre-dilute ready-to-use (478M-98), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (478M-98-RUO)
Well-differentiated liposarcoma is a malignant, non-metastasizing tumor that can present with similar histological characteristics as benign lipoma lesions and has a higher recurrence rate. The CDK4 protein is frequently overexpressed in well-differentiated liposarcoma due to gene amplification of the 12q13-15 chromosomal region that harbors the CDK4 gene, but amplification and subsequent overexpression is rarely observed in lipomas. Due to CDK4 protein expression differences between these lesions, anti-CDK4 antibody can be used in an immunohistochemistry panel as an aid in the differential diagnosis between well-differentiated liposarcoma and lipoma.1,2,3
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
