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Documentos

449R-1

Sigma-Aldrich

S100 beta (EP32) Rabbit Monoclonal Primary Antibody

Sinónimos:

S100 Calcium Binding Protein B

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About This Item

Código UNSPSC:
12352203

origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

EP32, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions

formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (449R-14)
vial of 0.1 mL concentrate Research Use Only (449R-14-RUO)
vial of 0.5 mL concentrate (449R-15)
vial of 1.0 mL concentrate (449R-16)
vial of 1.0 mL concentrate Research Use Only (449R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (449R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (449R-17)
vial of 7.0 mL pre-dilute ready-to-use (449R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (449R-18-RUO)

fabricante / nombre comercial

Cell Marque™

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotipo

IgG

control

melanoma

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic

Descripción general

S100 calcium binding protein B (S100 beta) is a member of the multifunctional S100 family of proteins. S100 beta acts as a stimulator of proliferation and migration and as an inhibitor of apoptosis and differentiation in many cell types including astrocytes, Schwann cells, chondrocytes, adipocytes, certain neuronal populations, melanocytes, Langerhans cells, histiocytes, epithelial, and myoepithelial cells. S100 beta is also expressed in neoplasms derived from these cell types, making it a useful marker for the identification of melanoma and various nervous system tumors. Although ubiquitous, S100 beta has proven to be a sensitive marker for malignant melanoma, including desmoplastic and metastatic variants.

Calidad


IVD
IVD
IVD
RUO

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

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Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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R Donato et al.
Current molecular medicine, 13(1), 24-57 (2012-07-28)
The S100 protein family consists of 24 members functionally distributed into three main subgroups: those that only exert intracellular regulatory effects, those with intracellular and extracellular functions and those which mainly exert extracellular regulatory effects. S100 proteins are only expressed
F Sedaghat et al.
Hippokratia, 12(4), 198-204 (2009-01-23)
The members of the S100 protein family are multifunctional proteins with a regulatory role in a variety of cellular processes. They exert their actions usually through calcium binding, although Zn2+ and Cu2+ have also been shown to regulate their biological
C deBlacam et al.
British journal of cancer, 105(1), 118-123 (2011-06-10)
Cutaneous melanoma is an aggressive disease. S100beta is an established biomarker of disease progression; however, the mechanism of its regulation in melanoma is undefined. Expression of HOXC11 and SRC-1 was examined by immunohistochemistry and immunofluorescence. Molecular and cellular techniques were
Markku Miettinen et al.
The American journal of surgical pathology, 38(3), 410-420 (2014-02-15)
The SALL4 transcription factor is associated with embryonic cell pluripotency and has been shown as a useful immunohistochemical marker for germ cell tumors. However, information of SALL4 distribution in normal human tissues and non-germ cell tumors is limited. In this

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