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Merck

338A-7

TdT Rabbit Polyclonal Antibody

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NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
9

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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (338A-74), vial of 0.5 mL concentrate (338A-75), bottle of 1.0 mL predilute (338A-77), vial of 1.0 mL concentrate (338A-76), bottle of 7.0 mL predilute (338A-78)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

control

thymus

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... DNTT(1791)

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Este artículo
MABE2043SAB4200224269A-1
antibody form

Ig fraction of antiserum

antibody form

purified antibody

antibody form

affinity isolated antibody

antibody form

Ig fraction of antiserum

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

species reactivity

human

species reactivity

human

species reactivity

mouse, human

species reactivity

human

clone

polyclonal

clone

41A, monoclonal

clone

polyclonal

clone

polyclonal

biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

technique(s)

immunofluorescence: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable

technique(s)

western blot: 1-2 μg/mL using HepG2 and NIH3T3 cell lysates

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

General description

TdT (terminal deoxynucleotidyl transferase) is a template-independent DNA polymerasethat adds nucleotides randomly to single-stranded DNA. This randomization plays a role inacquired immunity by increasing antigen receptor diversity and aiding in the generation ofimmunoglobulins and T-cell antigen receptors. TdT immunoreactivity is observed mainly in the thymus. Anti-TdT is often used to visualize lymphoblastic lymphomas and has also beenobserved in some cases of acute myeloid leukemia.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note


IVD

IVD

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]
TdT Positive Control Slides, Product No. 338S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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A Orazi et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 7(5), 582-586 (1994-06-01)
Terminal deoxynucleotidyl transferase (TdT) represents a useful marker for the diagnosis of acute lymphoblastic leukemia and lymphoblastic lymphoma. It is usually assayed in fresh tissue or cell suspensions by enzyme analysis, immunofluorescence, or immunoperoxidase. We have obtained satisfactory staining for
Ewing sarcoma vs lymphoblastic leukemia.
S Hirschl
American journal of clinical pathology, 115(6), 933-934 (2001-06-08)
R A Soslow et al.
Human pathology, 28(10), 1158-1165 (1997-10-29)
We propose that 12E7 (CD99) expression, along with TdT, bcl-2, and CD34 reactivity in lymphoblastic lymphoma (LyL)/acute lymphoblastic leukemia (ALL), distinguishes this group of neoplasms from small noncleaved cell lymphomas (SNCLs) in both pediatric and adult patients, thereby narrowing the
A Practical Approach to Diagnosis, 312-316 (1990)
R C Mathewson et al.
Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association, 17(6), 835-844 (1997-11-14)
In the differential diagnosis of small round cell tumors (SRCTs), terminal deoxynucleotidyl transferase (TdT) is often used as a marker for lymphoblastic lymphomas and leukemias. However, the specificity of TdT using the avidin-biotin-immunoperoxidase (ABC) method is not well documented. To

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SKUGTIN
338A-740841683136989
338A-750841683136996
338A-780841683137023
338A-760841683137009
338A-770841683137016

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