17936

1α,25-Dihydroxyvitamin D₃

≥97.0% (HPLC)

• Sinónimos: 1α,25-Dihydroxycholecalciferol, Calcitriol
• Fórmula empírica (notación de Hill): C₂₇H₄₄O₃
• Número de CAS: 32222-06-3
• Peso molecular: 416.64
• Beilstein: 7559394
• Número CE: 250-963-8
• Número MDL: MFCD00867079
• Código UNSPSC: 12352205
• eCl@ss: 34058003
• ID de la sustancia en PubChem: 57647688
• NACRES: NA.79

Propiedades

• Análisis: ≥97.0% (HPLC)
• formulario: crystals
• color: white to off-white
• temp. de almacenamiento: −70°C
• cadena SMILES: [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
• InChI: 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
• Clave InChI: GMRQFYUYWCNGIN-NKMMMXOESA-N
• Información sobre el gen: human ... VDR(7421)

Descripción

Descripción general

1α,25-Dihydroxyvitamin D₃, also referred as calcitriol, is a calcitrophic hormone. It is the most biologically active metabolite of vitamin D produced in proximal tubular cells in the kidney.

Aplicación

1α,25-Dihydroxyvitamin D₃ has been used to study its effect on transplantation success of human muscle precursor cells (hMPCs) in severe combined immunodeficient (SCID) mice in-vitro.

Acciones bioquímicas o fisiológicas

1α,25-Dihydroxyvitamin D₃ modulates energy metabolism by facilitating various metabolic processes, such as Ca²⁺ signaling and modulation of glucocorticoids, by affecting adipocyte apoptosis and by regulating the expression and production of multiple cytokines. In addition, it also modulates phosphorus homeostasis through actions in the intestine, kidney and bone. 1α,25-Dihydroxyvitamin D₃ exhibits antiproliferative effects and is used as a potent therapeutic for human prostate cancer.

Biologically active form of vitamin D₃ in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H300 + H310 + H330,H372
• Consejos de prudencia: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Clasificaciones de peligro: Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges