SMB00908
4-Hydroxy-4-methyl-2-oxoglutaric acid dipotassium salt
95-105% (titration)
Sinónimos:
4-Hydroxy-4-methyl-2-oxoglutaric acid dipotassium salt, Parapyruvate
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About This Item
Fórmula lineal:
C6H6K2O6
Número de CAS:
Peso molecular:
252.30
Código UNSPSC:
12352106
NACRES:
NA.25
Productos recomendados
Análisis
95-105% (titration)
formulario
powder
color
white to beige
solubilidad
water: soluble 10 mg/mL
Descripción general
Parapyruvate, also known as 4-hydroxy-4-methyl-2-oxoglutarate (HMOG), is a compound formed through the polymerization of two molecules of pyruvate via aldol condensation. It is closely related to α-ketoglutarate and is believed to act as a competitive inhibitor of the α-Ketoglutarate dehydrogenase complex (KGDHC) to form succinyl coenzyme A, impacting fibroblast senescence. A decrease in KGDHC activity is also associated with neurodegenerative disorders such as Alzheimer′s and Parkinson′s diseases. The precise mechanism of parapyruvate′s inhibition of KGDHC is complex, but it interferes with the activity of this rate-limiting enzyme in the tricarboxylic acid (TCA) cycle, ultimately affecting mitochondrial function. KGDHC is crucial for oxidative decarboxylation within the TCA cycle. Parapyruvate′s potential to inhibit KGDHC paves the way for research in cell biology and biochemistry, covering cell senescence, mitochondrial dysfunction, metabolic regulation, and aging-related diseases.
Aplicación
Parapyruvate can be used
- to study mitochondrial metabolomics
- to study age related disorders (Alzheimer′s and Parkinson′s research)
Acciones bioquímicas o fisiológicas
Parapyruvate is formed via an adol condensation reaction of pyruvate
Características y beneficios
High quality compound suitable for multiple research applications
Otras notas
For additional information on our range of Biochemicals, please complete this form.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Using Taguchi Method to Determine the Optimum Conditions for Synthesizing Parapyruvate
Lee et al.
Molecules (Basel), 27, 1870-1870 (2022)
Parapyruvate, an Impurity in Pyruvate Supplements, Induces Senescence in Human Fibroblastic Hs68 Cells via Inhibition of the ?-Ketoglutarate Dehydrogenase Complex
Chang SC et al.
Journal of Agricultural and Food Chemistry, 66, 7504-7513 (2018)
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