PHR1464

Dapsone

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: 4-Aminophenyl sulfone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, Bis(4-aminophenyl) sulfone, DDS, Dapsone
• Fórmula lineal: (H₂NC₆H₄)₂SO₂
• Número de CAS: 80-08-0
• Peso molecular: 248.30
• Beilstein: 788055
• Número CE: 201-248-4
• Número MDL: MFCD00007887
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823395
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to BP 102; traceable to Ph. Eur. D0100000; traceable to USP 1164008
• familia API: dapsone
• CofA: current certificate can be downloaded
• envase: pkg of 1 g
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• mp: 175-177 °C (lit.)
• aplicaciones: pharmaceutical (small molecule)
• formato: neat
• temp. de almacenamiento: 2-30°C
• cadena SMILES: Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2
• InChI: 1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
• Clave InChI: MQJKPEGWNLWLTK-UHFFFAOYSA-N

Descripción

Descripción general

Dapsone is an antibacterial drug, belongs to a class of compounds known as sulfones. It acts by inhibiting the synthesis of dihydrofolic acid through competition with para-aminobenzoate for the active site of dihydropteroate synthetase, thereby inhibiting the growth of microorganisms that are dependent on endogenous folic acid synthesis. It is used in primary treatment of dermatitis herpetiformis and in combination with other drugs to treat leprosy.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

Dapsone may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA3012 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Información de seguridad

• Pictogramas: GHS08,GHS07,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H302,H360F,H371,H373,H411
• Consejos de prudencia: P202 - P260 - P264 - P273 - P301 + P312 - P308 + P311
• Clasificaciones de peligro: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 1B - STOT RE 2 - STOT SE 2
• Órganos de actuación: Blood, Blood,spleen,Liver
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable