Saltar al contenido
Merck

F6145

Supelco

Fenspiride hydrochloride

analytical standard, for drug analysis

Sinónimos:

8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Fórmula empírica (notación de Hill):
C15H20N2O2 · HCl
Número de CAS:
Peso molecular:
296.79
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:

grado

analytical standard

Nivel de calidad

Análisis

>99% (TLC)

formulario

powder

técnicas

HPLC: suitable
gas chromatography (GC): suitable

color

white

aplicaciones

forensics and toxicology
pharmaceutical (small molecule)
veterinary

formato

neat

cadena SMILES

Cl.O=C1NCC2(CCN(CCc3ccccc3)CC2)O1

InChI

1S/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H

Clave InChI

FIKFLLIUPUVONI-UHFFFAOYSA-N

Aplicación

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Acciones bioquímicas o fisiológicas

Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.
Fenspiride hydrochloride possesses anti-allergic and anti-bronchoconstrictive properties. It is used as a drug to treat inflammatory conditions of the upper and lower respiratory tracts. Experimental studies state that fenspiride has an ability to reduce the development of myringosclerosis, possibly by restricting the formation of oxygen-derived free radicals.
Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


Choose from one of the most recent versions:

Certificados de análisis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

J Cortijo et al.
European journal of pharmacology, 341(1), 79-86 (1998-03-07)
We have investigated the role of human bronchial cyclic nucleotide phosphodiesterases in the effects of fenspiride, a drug endowed with bronchodilator and anti-inflammatory properties. Functional studies on human isolated bronchi showed that fenspiride (10(-6)-3 x 10(-3) M, 30 min) induced
J C Féray et al.
Biochemical pharmacology, 54(2), 293-297 (1997-07-15)
Fenspiride inhibits the calcium signal evoked by the inflammatory peptide formyl-Met-Leu-Phe (fMLP) in peritoneal macrophages, but at concentrations (approximately 1 mM) far above the therapeutic range (approximately 1 microM). Here, in rat alveolar macrophages, high fenspiride concentrations (1 mM) were
Inhibition of the development of myringosclerosis by local administration of fenspiride, an anti-inflammatory drug.
Mattsson C and Hellstrom S
European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 254(9-10), 425-429 (1997)
F Quartulli et al.
European journal of pharmacology, 348(2-3), 297-304 (1998-07-04)
Using the human lung epithelial WI26VA4 cell line, we investigated the capacity of fenspiride, an anti-inflammatory drug with anti-bronchoconstrictor properties, to interfere with histamine-induced intracellular Ca2+ increase and eicosanoid formation. Histamine and a histamine H1 receptor agonist elicited a rapid

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico