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Merck
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Documentos

B5899

Supelco

Buflomedil hydrochloride

analytical standard

Sinónimos:

4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone

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About This Item

Fórmula empírica (notación de Hill):
C17H25NO4 · HCl
Número de CAS:
35543-24-9
Peso molecular:
343.85
Número CE:
252-611-9
Número MDL:
MFCD00078965
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329773268
NACRES:
NA.24

grado

analytical standard

Nivel de calidad

200

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

forensics and toxicology
pharmaceutical (small molecule)
veterinary

formato

neat

cadena SMILES

Cl.COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1

InChI

1S/C17H25NO4.ClH/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18;/h11-12H,4-10H2,1-3H3;1H

Clave InChI

ZDPACSAHMZADFZ-UHFFFAOYSA-N

Información sobre el gen

human ... EBP(10682)

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Descripción general

Buflomedil hydrochloride is a vasoactive agent. Its mode of action involves increasing the peripheral and cerebral blood flow in ischaemic tissues of patients, who are mostly affected with vascular diseases.

Aplicación

Buflomedil hydrochloride may be used as an analytical standard for the determination of buflomedil in biological matrices using high-performance liquid chromatography technique. It may also be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations and serum samples using electroanalytical and chromatographic techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
038F09711
038F0971

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Paul P Dobesh et al.
Pharmacotherapy, 29(5), 526-553 (2009-04-29)
Peripheral artery disease, defined as atherosclerosis in the lower extremities, affects nearly 8.5 million people in the United States. Due to the frequent asymptomatic manifestation of peripheral artery disease, diagnosis may be delayed and its true incidence underestimated. However, some
Danik Arana Navarte et al.
Medical problems of performing artists, 26(2), 79-83 (2011-06-23)
Determine the safety and tolerance of mesotherapy as a technique for the treatment of musculoskeletal complaints in musicians. 67 patients (55.2% women) were subjected to a total of 267 mesotherapy sessions. A mesotherapy needle or normal needle was used randomly.
Buflomedil: still too many fatal cardiac and neurological events.
Prescrire international, 20(115), 99-99 (2011-06-09)
Claudio Bucolo et al.
Pharmacoepidemiology and drug safety, 21(11), 1190-1196 (2012-08-03)
Review all the individualized cases of adverse drug reaction (ADR) potentially related to buflomedil, a vasodilator with the indication for peripheral arterial disease (PAD), marketed in Europe since the 1970s but recently suspended by the European Medicines Agency. A review
Quantification of the Vasoactive Agent Buflomedil HCl in Pharmaceutical Formulation and Human Serum by Stripping Voltammetry and Liquid Chromatography
El-Desoky.SH, et al.
Acta Chimica Slovenica, 57(2), 18-21 (2010)
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