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Merck

90594

Supelco

Bisdemethoxycurcumin

analytical standard

Sinónimos:

(E,E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, Bisdesmethoxycurcumin, Curcumin III, Didemethoxycurcumin

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About This Item

Fórmula empírica (notación de Hill):
C19H16O4
Número de CAS:
Peso molecular:
308.33
Beilstein:
3149384
Número MDL:
Código UNSPSC:
85151701
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

analytical standard

Nivel de calidad

Análisis

≥95.0% (HPLC)

caducidad

limited shelf life, expiry date on the label

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

food and beverages

formato

neat

cadena SMILES

Oc1ccc(cc1)\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2

InChI

1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+

Clave InChI

PREBVFJICNPEKM-YDWXAUTNSA-N

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Aplicación

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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James R Fuchs et al.
Bioorganic & medicinal chemistry letters, 19(7), 2065-2069 (2009-03-03)
Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC(50) values in sub-micromolar range, fifty times
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Bioorganic & medicinal chemistry, 16(17), 8035-8041 (2008-08-06)
Series of curcumin derivatives were synthesized; the inhibitory activities on thioredoxin reductase (TrxR) of all analogues were evaluated by DTNB assay in vitro. It is found that most of the analogues can inhibit TrxR in the low micromolar range; Structure-activity
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Journal of experimental & clinical cancer research : CR, 22(1), 77-83 (2003-05-03)
In this study, some of the synthetic curcuminoid derivatives are analyzed for their anti-angiogenic activity. Intraperitoneal administration of the compounds tetrahydrocurcumin (THC), salicyl curcumin (SC) and curcuminIII (C-III) reduced the number of tumour directed capillaries induced by injecting B16F-10 melanoma
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Bioorganic & medicinal chemistry letters, 19(3), 706-709 (2008-12-30)
Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was validated by showing that curcumin inhibits the activity of M. SssI with

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