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37095

Supelco

Staurosporine

VETRANAL®, analytical standard

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About This Item

Fórmula empírica (notación de Hill):
C28H26N4O3
Número de CAS:
62996-74-1
Peso molecular:
466.53
Número MDL:
MFCD00077402
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329755625
NACRES:
NA.24

grado

analytical standard

Nivel de calidad

100

Línea del producto

VETRANAL®

caducidad

limited shelf life, expiry date on the label

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

forensics and toxicology
pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

−20°C

cadena SMILES

CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

InChI

1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1

Clave InChI

HKSZLNNOFSGOKW-ZGQXJOJZSA-N

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Descripción general

Staurosporine belongs to the class of indolocarbazole alkaloids and shows anti-fungal and anti-oomycete activities. It is isolated from Streptomyces sp. and is known to be a broad-spectrum inhibitor of protein kinase.

Aplicación


  • Protein Painting for Structural Analysis: This research utilizes staurosporine′s role in protein kinase inhibition to develop a technique called protein painting, which is essential for structural and binding site analysis. This approach enhances understanding of protein interactions and can be pivotal in drug design, particularly in targeting specific kinase enzymes in cancer research (Zheng Z et al., 2024).

  • Identification of Anthelmintic Activities: Staurosporine is employed to identify small molecule inhibitors that target conserved proteins among gastrointestinal nematodes. This study not only highlights its role in parasitic infection treatments but also its broader applications in developing antiparasitic drugs, leveraging its properties as a potent kinase inhibitor (Jung H et al., 2024).

  • Development of Novel Cytoprotective Compounds: Focusing on mitochondria-dependent cell death, this research explores staurosporines potential to inhibit pathways involved in cellular apoptosis. This is particularly crucial in developing therapeutic strategies against diseases characterized by unwanted cell death, such as neurodegenerative diseases and certain types of cancer (Matsuyama M et al., 2023).

Otras notas

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Información legal

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Health hazard
GHS08

Palabra de señalización

Warning

Frases de peligro

H361d,H413

Clasificaciones de peligro

Aquatic Chronic 4 - Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
BCCJ6830
BCCH5171
BCCF1431
BCCC2217
BCBX0018

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Karin Anestål et al.
PloS one, 3(4), e1846-e1846 (2008-04-03)
SecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of its selenocysteine (Sec) residue with electrophiles, or by its removal through C-terminal truncation. SecTRAPs are devoid of thioredoxin reductase activity but
A Gescher
General pharmacology, 31(5), 721-728 (1998-11-11)
1. Protein kinase C (PKC) is a family of serine/threonine-directed protein kinases that are pivotal regulators of cellular growth, transformation and death. PKC has therefore been considered to be a suitable target for novel antineoplastic drugs. 2. Twenty years ago
S Ståhl et al.
Cell death & disease, 4, e454-e454 (2013-01-11)
Radiation therapy is frequently used to treat non-small cell lung cancers (NSCLCs). We have previously shown that a combination of ionizing radiation (IR) and the staurosporine analog PKC 412, but not Ro 31-8220, increases cell death in NSCLC cells. To
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.
U T Rüegg et al.
Trends in pharmacological sciences, 10(6), 218-220 (1989-06-01)
Osman A B S M Gani et al.
Natural product reports, 27(4), 489-498 (2010-03-26)
The isolation in 1977 of the microbial alkaloid staurosporine inaugurated research into several distinct series of related natural and synthetic compounds. This has especially included research into applications as anticancer drugs, beginning with the observation of low nanomolar inhibition of
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