SCT056
BioTracker QUMA-1 RNA G-quadruplex Live Cell Dye
A red-emitting fluorescent probe for tracking RNA G-quadruplexes dynamics, such as folding and unfolding, in live cells.
Sinónimos:
Live cell imaging probe
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About This Item
Código UNSPSC:
12352207
NACRES:
NA.47
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Análisis
≥98% (H-NMR)
≥98% (HPLC)
≥98% (LC/MS)
≥98% (elemental analysis)
técnicas
cell based assay: suitable
método de detección
fluorometric
Descripción general
RNA G-quadruplexes are formed by self-assembly of guanine-rich RNA stacks into stacked G-quartets. This can occur in protein-coding (mRNA) as well as non-coding (ncRNA) transcripts. There is growing evidence that RNA G-quadruplexes are involved in different biological functions: telomere elongation, DNA recombination, transcription, RNA post-transcriptional mechanisms (pre-mRNA processing, mRNA turnover, targeting and translation), and are associated with sevral human diseases.
BioTracker<TMSYMBOL></TMSYMBOL> QUMA-1 RNA G-quadruplex Live Cell Dye (QUMA-1) is a red-emitting fluorescent probe that can be used to study dynamics (folding and unfolding) and movements of RNA G-quadruplexes. QUMA-1 is a reversible dye that emits upon binding to G-quadruplexes and turns off upon unfolding. QUMA-1 is highly specific for RNA G-quadruplexes and does not bind to DNA, double-stranded RNA, single-stranded RNA or other RNA structures. QUMA-1 could also potentially be used to study RNA-protein interactions.
Spectral Properties
Absorbance: 555 nm
Emission: 660 nm
BioTracker<TMSYMBOL></TMSYMBOL> QUMA-1 RNA G-quadruplex Live Cell Dye (QUMA-1) is a red-emitting fluorescent probe that can be used to study dynamics (folding and unfolding) and movements of RNA G-quadruplexes. QUMA-1 is a reversible dye that emits upon binding to G-quadruplexes and turns off upon unfolding. QUMA-1 is highly specific for RNA G-quadruplexes and does not bind to DNA, double-stranded RNA, single-stranded RNA or other RNA structures. QUMA-1 could also potentially be used to study RNA-protein interactions.
Spectral Properties
Absorbance: 555 nm
Emission: 660 nm
Aplicación
A red-emitting fluorescent probe for tracking RNA G-quadruplexes dynamics, such as folding and unfolding, in live cells.
Live cell fluorescent imaging
Research Category
Cell Imaging
microRNA
RNA Metabolism & Binding Proteins
Cell Imaging
microRNA
RNA Metabolism & Binding Proteins
Research Sub Category
Live Cell Dye
Live Cell Dye
Calidad
Purity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 628.17 g/mol
Molar Mass: 628.17 g/mol
Forma física
Lyophilized
Almacenamiento y estabilidad
Store BioTracker QUMA-1 RNA G-quadruplex -Live Cell Dye at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Otras notas
Concentration: Please refer to lot specific datasheet.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Xiu-Cai Chen et al.
Angewandte Chemie (International ed. in English), 57(17), 4702-4706 (2018-02-18)
Because of the absence of methods for tracking RNA G-quadruplex dynamics, especially the folding and unfolding of this attractive structure in live cells, understanding of the biological roles of RNA G-quadruplexes is so far limited. Herein, we report a new
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