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MMMP2MAG-79K

Millipore

MILLIPLEX® Mouse MMP Magnetic Bead Panel 2 - Immunology Multiplex Assay

TIMP Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple TIMP biomarkers in mouse serum, plasma and cell culture samples.

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About This Item

Código UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Nivel de calidad

200

reactividad de especies

mouse

fabricante / nombre comercial

Milliplex®

assay range

standard curve range: 12-50,000 pg/mL
(proMMP-9)
standard curve range: 5-20,000 pg/mL
(MMP-12)

técnicas

multiplexing: suitable

método de detección

fluorometric (Luminex xMAP)

Condiciones de envío

wet ice

Categorías relacionadas

Descripción general

The MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in autoimmune disease, arthritis, cardiovascular disease, and tumor growth and metastasis.

MILLIPLEX® Mouse MMP Bead Panel 2, MMMP2MAG-79K, is a 2 plex kit to be used for the simultaneous quantification of the following analytes in serum/plasma samples: proMMP-9 and MMP-12.

Panel Type: Cytokines/Chemokines

Especificidad

Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

Aplicación

  • Analytes: proMMP-9, MMP-12
  • Recommended Sample type: serum or plasma
  • Recommended Sample dilution: 1:2
  • Assay Run Time: overnight or one day
  • Research Category: Inflammation & Immunology

Características y beneficios

Design your multiplex kit by choosing available analytes within this panel.

Almacenamiento y estabilidad

Recommended storage for kit components is 2 - 8°C.

Otras notas

Sensitivity: See protocol for sensitive’s of individual analytes

Información legal

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Órganos de actuación

Respiratory Tract

Código de clase de almacenamiento

10 - Combustible liquids

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Alexandra Noël et al.
Frontiers in physiology, 12, 704401-704401 (2021-12-17)
Matrix metalloproteinase-12 (Mmp12) is upregulated by cigarette smoke (CS) and plays a critical role in extracellular matrix remodeling, a key mechanism involved in physiological repair processes, and in the pathogenesis of emphysema, asthma, and lung cancer. While cigarette smoking is

Contenido relacionado

Immunology Multiplex Assays | MILLIPLEX®

Immunology multiplex assays like MILLIPLEX® allow simultaneous investigation of immune biomarkers, saving time and resources in research.

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