MABT401
Anti-Lubricin Antibody/Proteoglycan 4, clone 9G3
clone 9G3, from mouse
Sinónimos:
Proteoglycan 4, Lubricin, Megakaryocyte-stimulating factor, Superficial zone proteoglycan, Proteoglycan 4 C-terminal part
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
9G3, monoclonal
reactividad de especies
rat, human
técnicas
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotipo
IgG1κ
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... PRG4(10216)
Descripción general
The protein called Lubricin/Proteoglycan 4 is an important secreted protein in the joint critical for joint function and thus is also a focus of research in joint diseases as well. Lubricin/Proteoglycan 4 plays a role in boundary lubrication and prevents the deposition of cartilage from the synovial fluid by controlling the synovial growth of the synovial cells and inhibiting the adhesion of the cells to the cartilage surface. During development, Lubricin/Proteoglycan 4 also acts as a growth factor for hematopoietic and endothelial cell lineages, and Lubricin/Proteoglycan 4 appears important for proper barrier and lubrication development in tissues like the eye. Lubricin/Proteoglycan 4 is highly expressed in joints and near joint boundaries but can also be found in the brain, heart, lung, kidney and other tissues. Lubricin/Proteoglycan 4 has several isoforms that differ in their cell and tissue expression. Isoform C and D are the most widely expressed forms. Finally because of its effects on surfaces, Lubricin/Proteoglycan 4 is being examined in tissue engineering and artificial cartilage development as a treatment for joint diseases.
Inmunógeno
Recombinant protein corresponding to human Lubricin/Proteoglycan 4.
Aplicación
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Lubricin/Proteoglycan 4 in human liver and human heart tissue.
Immunohistochemistry Analysis: A representative lot detected Lubricin/Proteoglycan 4 in articular cartilage tissue (Elsaid, K.A, et al. (2012). Osteoarthritis and Cartilage. 20:940-948).
Immunohistochemistry Analysis: A representative lot detected Lubricin/Proteoglycan 4 in rat arterial cartilage tissue (Jay, G.D, et al. (2012). Arthritis & Rheumatism. 64(4):940-948).
Immunohistochemistry Analysis: A representative lot detected Lubricin/Proteoglycan 4 in articular cartilage from rat
(Manuscript in preparation).
Western Blotting Analysis: A representative lot detected Lubricin/Proteoglycan 4 in lubricin purified from synovial fluid of patients (Manuscript in preparation).
Immunohistochemistry Analysis: A representative lot detected Lubricin/Proteoglycan 4 in articular cartilage tissue (Elsaid, K.A, et al. (2012). Osteoarthritis and Cartilage. 20:940-948).
Immunohistochemistry Analysis: A representative lot detected Lubricin/Proteoglycan 4 in rat arterial cartilage tissue (Jay, G.D, et al. (2012). Arthritis & Rheumatism. 64(4):940-948).
Immunohistochemistry Analysis: A representative lot detected Lubricin/Proteoglycan 4 in articular cartilage from rat
(Manuscript in preparation).
Western Blotting Analysis: A representative lot detected Lubricin/Proteoglycan 4 in lubricin purified from synovial fluid of patients (Manuscript in preparation).
This Anti-Lubricin Antibody/Proteoglycan 4, clone 9G3 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Lubricin/Proteoglycan 4.
Calidad
Evaluated by Western Blotting in Lubricin purified protein.
Western Blotting Analysis: 0.02 µg/mL of this antibody detected Lubricin/Proteoglycan 4 in 1 µg of Lubricin purified protein.
Western Blotting Analysis: 0.02 µg/mL of this antibody detected Lubricin/Proteoglycan 4 in 1 µg of Lubricin purified protein.
Descripción de destino
~220 kDa observed. The calculated molecular weight of this protein is 151 kDa with many isoforms observed around 145 kDa and it can run higher due to glycosylation.
Forma física
Format: Purified
Otras notas
Concentration: Please refer to lot specific datasheet.
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Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Tryptase I? regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis.
Das, et al.
Nature Communications, 14, 1910-1910 (2023)
Elizabeth Feeney et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 37(5), 1071-1079 (2019-03-13)
The objective of this study was to examine temporal variations in synovial fluid composition and lubrication following articular fracture. Post-traumatic osteoarthritis (PTOA) was induced by creating an osteochondral fracture in the middle carpal joint of four horses while the contralateral
R M Irwin et al.
Osteoarthritis and cartilage, 28(4), 492-501 (2020-02-28)
Viscosupplementation has been used for decades to treat mild to moderate osteoarthritis, yet it is unknown if the lubricating function of different pathological synovial fluids (SF) vary, or if they respond differentially to viscosupplementation. The objectives of this study were
Zhong Li et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9(21), e2105909-e2105909 (2022-04-19)
Diseases of the knee joint such as osteoarthritis (OA) affect all joint elements. An in vitro human cell-derived microphysiological system capable of simulating intraarticular tissue crosstalk is desirable for studying etiologies/pathogenesis of joint diseases and testing potential therapeutics. Herein, a
Amanda Watkins et al.
BMC veterinary research, 17(1), 189-189 (2021-05-14)
Lameness is a debilitating condition in equine athletes that leads to more performance limitation and loss of use than any other medical condition. There are a limited number of non-terminal experimental models that can be used to study early inflammatory
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