MABN665
Anti-Synaptotagmin-7 Antibody, clone N275/14
clone N275/14, from mouse
Sinónimos:
Synaptotagmin-7, Synaptotagmin VII, SytVII
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
N275/14, monoclonal
reactividad de especies
mouse, human, rat
técnicas
immunohistochemistry: suitable
western blot: suitable
isotipo
IgG2bκ
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... SYT7(9066)
Categorías relacionadas
Descripción general
Synaptotagmin-7 is also referred to as Synaptotagmin VII (SytVII) and is a member of the synaptotagmin family of transmembrane transporters. Synaptotagmin-7 is involved in plasma membrane repair, and possibly Ca2+-dependent exocytosis and traffiking of secretory vesicles.
Especificidad
This antibody recognizes the cytoplasmic C2A domain of Synaptotagmin-7. This antibody does not cross react with Synaptotagmin-6 or other Synaptotagmins (Prof. J. Trimmer, University of California, Davis.).
Inmunógeno
Epitope: Cytoplasmic C2A domain
Recombinant protein corresponding to the cytoplasmic C2A domain of mouse Synaptotagmin-7.
Aplicación
Anti-Synaptotagmin-7 Antibody, clone N275/14 is a highly specific mouse monoclonal antibody, that targets Synaptotagmin & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Synaptotagmin-7 in human thalamus tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
Calidad
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Synaptotagmin-7 in 10 µg of mouse brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Synaptotagmin-7 in 10 µg of mouse brain tissue lysate.
Descripción de destino
~ 45 kDa observed. Uncharacterized band(s) may appear in some lysates.
Forma física
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Almacenamiento y estabilidad
Stable for 1 year at 2-8°C from date of receipt.
Nota de análisis
Control
Mouse brain tissue lysate
Mouse brain tissue lysate
Otras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Synaptotagmin-7 Enhances Facilitation of Cav2.1 Calcium Channels.
Djillani, et al.
eNeuro, 9 (2023)
Gaël Barthet et al.
Nature communications, 9(1), 4780-4780 (2018-11-16)
Mutations of the intramembrane protease presenilin (PS) or of its main substrate, the amyloid precursor protein (APP), cause early-onset form of Alzheimer disease. PS and APP interact with proteins of the neurotransmitter release machinery without identified functional consequences. Here we
Christopher Weyrer et al.
Cell reports, 36(12), 109719-109719 (2021-09-23)
Synaptotagmin 7 (Syt7) is a high-affinity calcium sensor that is implicated in multiple aspects of synaptic transmission. Here, we study the influence of Syt7 on the climbing fiber (CF) to Purkinje cell (PC) synapse. We find that small facilitation and
Bassam Tawfik et al.
eLife, 10 (2021-03-23)
Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca2+-sensors for vesicle fusion in mouse chromaffin cells. When
Katarina Trajkovic et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(37), 9000-9012 (2017-08-20)
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by the expansion of a CAG triplet in the gene encoding for huntingtin (Htt). The resulting mutant protein (mHtt) with extended polyglutamine (polyQ) sequence at the N terminus leads to neuronal
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