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HGAMMAG-301K

Millipore

MILLIPLEX® Human Isotyping Magnetic Bead Panel - Isotyping Multiplex Assay

Isotyping Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple immunoglobulins (Ig) in human serum, plasma and cell culture samples.

Sinónimos:

Human Ig isotype multiplex panel, Human immune globulin multiplex panel, Human immunoglobulin multiplex kit, Luminex® human immunoglobulin immunoassay, Millipore Human immunoglobulin panel

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About This Item

Código UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.47

Nivel de calidad

200

reactividad de especies

human

fabricante / nombre comercial

Milliplex®

assay range

accuracy: 88-99%
sensitivity: 0.08 ng/mL
(IgG4)
sensitivity: 0.09 ng/mL
(IgG3)
sensitivity: 0.47 ng/mL
(IgM)
sensitivity: 1.5 ng/mL
(IgA)
sensitivity: 10 ng/mL
(IgG1)
sensitivity: 85 ng/mL
(IgG2)
standard curve range: 0.2-150 ng/mL
(IgG3)
standard curve range: 0.4-300 ng/mL
(IgG4)
standard curve range: 14-10,000 ng/mL
(IgG1)
standard curve range: 2.1-1,500 ng/mL
(IgA)
standard curve range: 3.4-2,500 ng/mL
(IgM)
standard curve range: 41-30,000 ng/mL
(IgG2)

técnicas

multiplexing: suitable

método de detección

fluorometric (Luminex xMAP)

Condiciones de envío

wet ice

Categorías relacionadas

Descripción general

Produced by plasma cells and lymphocytes, immunoglobulins (antibodies) are critically involved in immune response, attaching to antigens, and playing a role in their destruction. Immunoglobulins (Ig) can be classified by isotype, classes that differ in function and antigen response due to structure variability. Five major isotypes have been identified in placental mammals: IgM, IgG, IgA, IgE and IgD (B-cell receptor) – all found in normal individuals. Immunoglobulin-deficiency disorders, such as autoimmune disease, some GI conditions, and malignancies, are characterized by specific isotype deficiencies or varying concentrations of one or more isotypes. Disease states can range from the absence of one isotype class or subclass to a total deficiency of immunoglobulin classes. In addition, isotyping applications include analyzing hybridomas during antibody generation and vaccine development.

The MILLIPLEX® Human Isotyping Bead Panel, measuring human IgG subclasses (1, 2, 3, 4), IgM and IgA is designed to enable you to measure both classes and subclasses accurately – all in one well. In addition, this panel allows you to choose only those immunoglobulins you need for your experiments.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Immune Response

Aplicación

  • Analytes: IgG1, IgG2, IgG3, IgG4, IgA, IgM
  • Recommended Sample type: Serum, plasma, or tissue/cell lysate and culture supernatant samples
  • Recommended Sample dilution: 1:16,000 diluted plasma or serum, or cell culture supernatant diluted to approximately 1μg/mL Ig per well
  • Assay Run Time: One day
  • Research Category: Inflammation & Immunology

Características y beneficios

Design your multiplex kit by choosing available analytes within this panel.

Componentes

MILLIPLEX MAP Anti-Human κ and λ Light Chain, PE

MILLIPLEX MAP Human Multi-Immunoglobulin Standard

MILLIPLEX MAP Human Immunoglobulin Positive Control

MILLIPLEX MAP Assay Buffer

MILLIPLEX MAP Wash Buffer, 10X

Información legal

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Órganos de actuación

Respiratory Tract

Código de clase de almacenamiento

10 - Combustible liquids

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Brian K McFarlin et al.
Journal of dietary supplements, 10(3), 171-183 (2013-08-10)
Strenuous exercise, such as running a marathon, is known to suppress mucosal immunity for up to 24 hr, which can increase the risk of developing an upper respiratory tract infection (URTI) and reduced performance capacity (Allgrove JE, Geneen L, Latif
Jiong Wang et al.
Frontiers in immunology, 12, 696370-696370 (2021-08-14)
The COVID-19 pandemic is caused by SARS-CoV-2, a novel zoonotic coronavirus. Emerging evidence indicates that preexisting humoral immunity against other seasonal human coronaviruses (HCoVs) plays a critical role in the specific antibody response to SARS-CoV-2. However, current work to assess
Rukmani Lekhraj et al.
Scientific reports, 12(1), 6934-6934 (2022-04-29)
The immune system has been described to play a role in the development of Alzheimer's disease (AD), but the distribution of immunoglobulins and their subclasses in brain tissue has not been explored. In this study, examination of pathologically diagnosed frontal
B G Jones et al.
Clinical and experimental immunology, 183(2), 239-247 (2015-10-02)
Vitamin A supports the induction of immunoglobulin (Ig)A responses at mucosal surfaces in mice, but much less is known about the influence of vitamins on antibody isotype expression in humans. To address this knowledge gap, we examined 46 residual blood
Panagiotis Karagiannis et al.
Oncoimmunology, 4(11), e1032492-e1032492 (2015-10-10)
Emerging evidence suggests pathological and immunoregulatory functions for IgG4 antibodies and IgG4+ B cells in inflammatory diseases and malignancies. We previously reported that IgG4 antibodies restrict activation of immune effector cell functions and impair humoral responses in melanoma. Here, we
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