FCMAB196P

Milli-Mark^® Anti-CD42b-PE Antibody, clone AN51

clone AN51, Milli-Mark^®, from mouse

• Sinónimos: Platelet glycoprotein Ib alpha chain, Glycoprotein Ibalpha, GP-Ib alpha, GPIb-alpha, GPIbA, Antigen CD42b-alpha
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.44

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: PE
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: AN51, monoclonal
• reactividad de especies: human
• fabricante / nombre comercial: Milli-Mark^®
• técnicas: flow cytometry: suitable
• isotipo: IgG2aκ
• Nº de acceso NCBI: NP_000164
• Nº de acceso UniProt: P07359
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... GP1BA(2811)

Descripción

Descripción general

CD42b is a 145 kDa protein, which together with CD42c forma a 160 kDa heterodimer composed of an alpha-chain and a beta-chain, respectively. The subunits are linked together by a disulphide bond. CD42b and CD42c forms a non-covalent complex together with CD42a and CD42d in the platelet plasma membrane. The CD42 complex serves as a receptor for von Willebrand factor and thrombin and mediates adhesion of platelets to subendothelial matrices (exposed upon damage to the endothelium) at high shear rates. The binding sites for von Willebrand factor and thrombin lies on CD42b (de Haas, 2002). CD42 is expressed on megakarytocytes and platelets (McMichael, 1981).

Especificidad

Antibody recognizes Human CD42b antigen.

Inmunógeno

Mixture of human platelets and lymphocytes.

Aplicación

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

This Milli-Mark Anti-CD42b-PE Antibody, clone AN51 is validated for use in FC for the detection of CD42b.

Calidad

Evaluated by flow cytometry using human lymphocytes

Descripción de destino

145 kDa (de Haas, 2002)

Forma física

Protein A purified

Purified Mouse monoclonal IgG2a conjugated to PE in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

Almacenamiento y estabilidad

Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Nota de análisis

Control
Human Lymphocytes

Información legal

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable