ABS192

Anti-phospho-SRPK2 (Ser497) Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: SRSF protein kinase 2, SFRS protein kinase 2, Serine/arginine-rich protein-specific kinase 2, SR-protein-specific kinase 2, SRSF protein kinase 2 N-terminal, SRSF protein kinase 2 C-terminal
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: hamster, mouse, human
• reactividad de especies (predicha por homología): rat (based on 100% sequence homology), Xenopus (based on 100% sequence homology)
• técnicas: western blot: suitable
• Nº de acceso NCBI: NP_872633
• Nº de acceso UniProt: P78362
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: phosphorylation (pSer497)
• Información sobre el gen: human ... SRPK2(6733)

Descripción

Descripción general

SRPK2 is also known as SRSF protein kinase 2, SFRS protein kinase 2, and Serine/arginine-rich protein-specific kinase 2. SRPK2 is a kinase which is involved in the phosphorylation of SR splicing factors, and the regulation of splicing. SRPK2 also promotes neuronal apoptosis, plays an essential role in splicesomal B complex formation, and mediates hepatitis B virus (HBV) replication and core protein phosphorylation. SRPK2 is highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney.

Especificidad

This antibody recognizes the protein kinase domain of SRPK2 phosphorylated at Ser497.

Inmunógeno

Epitope: Protein kinase domain

KLH-conjugated linear peptide corresponding to the protein kinase domain of human SRPK2 (Ser497).

Aplicación

Anti-phospho-SRPK2 (Ser497) Antibody is a highly specific rabbit polyclonal antibody, that targets SRPK & has been tested in western blotting.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Calidad

Evaluated by Western Blotting in NIH3T3 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected SRPK2 (Ser497) in 10 µg of NIH3T3 cell lysate and Insulin treated NIH3T3 cell lysate.

Descripción de destino

~120 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~77 kDa and ~79 kDa Uniprot states 8 phosphorylation sites are known to exist.

Forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
NIH3T3 cell lysate and Insulin treated NIH3T3 cell lysate

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable