ABN87
Anti-DSCR3 Antibody
from rabbit, purified by affinity chromatography
Sinónimos:
Down syndrome critical region protein 3, Down syndrome critical region protein A
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
purificado por
affinity chromatography
reactividad de especies
human
técnicas
immunohistochemistry: suitable (paraffin)
western blot: suitable
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... VPS26C(10311)
Descripción general
Trisomy of human chromosome 21 result in patients with Down′s syndrome, which is a complex developmental and neurodegenerative disease that is characterized with abnormal morphological features, hypotonia, and mental retardation. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region. DSCR3 expresses Down syndrome critical region protein 3, which is reportedly expressed in many studied tissues. While it is suggested that this protein is involved in neuroexcitation and in cellular signaling, further study is still required to elucidate its role and mechanism of action.
Especificidad
Other homologies: Rat and Mouse (92% sequence homology).
Inmunógeno
KLH-conjugated linear peptide corresponding to human DSCR3.
Aplicación
Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected DSCR3 in human gastric tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
This Anti-DSCR3 Antibody is validated for use in WB, IH(P) for the detection of DSCR3.
Calidad
Evaluated by Western Blot in A549 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected DSCR3 in 10 µg of A549 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected DSCR3 in 10 µg of A549 cell lysate.
Descripción de destino
~39 kDa observed. An uncharacterized band may be observed at a molecular weight of ~160 kDa in some cell lysates.
Forma física
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Almacenamiento y estabilidad
Stable for 1 year at 2-8°C from date of receipt.
Nota de análisis
Control
A549 cell lysate
A549 cell lysate
Otras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Kerrie E McNally et al.
Nature cell biology, 19(10), 1214-1225 (2017-09-12)
Following endocytosis into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multiprotein complex that orchestrates cargo retrieval
Michael D Healy et al.
Cell, 186(10), 2219-2237 (2023-05-13)
The Commander complex is required for endosomal recycling of diverse transmembrane cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies: Retriever composed of VPS35L, VPS26C, and VPS29; and the CCC complex which contains twelve subunits: COMMD1-COMMD10 and the
Rebeka Butkovič et al.
Nature communications, 15(1), 7180-7180 (2024-08-22)
Commander is a multiprotein complex that orchestrates endosomal recycling of integral cargo proteins and is essential for normal development. While the structure of this complex has recently been described, how cargo proteins are selected for Commander-mediated recycling remains unclear. Here
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