ABN180

Anti-TFG Antibody

from rabbit

• Sinónimos: Protein TFG, TRK-fused gene protein
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• reactividad de especies: rat, mouse, human
• técnicas: immunohistochemistry: suitable (paraffin); western blot: suitable
• Nº de acceso NCBI: NP_001007566
• Nº de acceso UniProt: Q92734
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TFG(10342)

Descripción

Descripción general

The TRK-fused gene protein (TFG) gene is highly conserved among mammalian species, and is widely studied as a fusion gene partnering with various oncogenes. The function of the resultant TFG protein product is still unclear. TFG regulates the activity of phosphotyrosine-specific phosphatase-1 (SHP-1), and may be important in cells containing SHP-1 such as epithelial and neuronal cells. Defective TFG contributes to thyroid papillary carcinoma.

Especificidad

This antibody recognizes the C-terminus of TFG.

Inmunógeno

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human TFG.

Aplicación

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

This Anti-TFG Antibody is validated for use in Western Blotting, IHC(P) for the detection of TFG.

Western Blot Analysis: 0.1 µg/mL from a representative lot detected TFG on 10 µg of human brain tissue lysate.

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TFG in mouse hippocampus, mouse cerebellum, human placenta, and human pancreas tissues.

Calidad

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected TFG on 10 µg of HeLa cell lysate.

Descripción de destino

~56 kDa observed. The calculated molecular weight is 43 kDa, however TFG has been shown as a ~56 kDa band in western blots (Greco, A., et al. (1995). Molecular and Cellular Biology. 15(11):6118–6127.)

Forma física

Format: Purified

Protein A purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
HeLa cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable