ABN1011

Anti-Peroxiredoxin-2 Antibody

serum, from rabbit

• Sinónimos: Peroxiredoxin-2, Thiol-specific antioxidant protein, TSA, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: serum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• reactividad de especies: rat, human, mouse
• técnicas: immunocytochemistry: suitable; western blot: suitable
• Nº de acceso NCBI: NP_035693
• Nº de acceso UniProt: Q61171
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PRDX2(7001)

Descripción

Descripción general

The protein called Peroxiredoxin-2, or in older literature Thiol-specific antioxidant protein, TSA, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Natural killer cell-enhancing factor B, PRP, or NKEF-B and encoded by the human gene PRDX2/NKEFB/TDPX1 plays a role in controlling the oxidation state of the cell by reducing peroxides via the Thioredoxin system. Peroxides are produced during normal metabolism and if not reduced, their built up can lead to oxidative stress and cell death. Interestingly Peroxirdoxin-2 can be inactivated itself by oxidative stress on Cys-51 thus its levels are tightly controlled. Peroxiredoxin-2 is particularly important in neurons where it acts as an anti-apoptotic factor but the protein is widely expressed and localizes to the cytoplasm in most cells. Because Peroxiredoxin-2 mediates H2O2 signaling it is considered an anti-aging and anti-cancer protein, but surprisingly recent research in yeast indicates that Peroxiredoxin-2 potentiates H202 levels and signaling by specifically inhibiting other Thioredoxin enzymes via their oxidation. Thus Peroxiredoxin-2 can both inhibit and promote peroxide metabolism depending upon the cellular microenvironment and cell systems being studied.

Inmunógeno

Epitope: C-terminus

Ovalbumin-conjugated linear peptide corresponding to the C-terminus of mouse Peroxiredoxin-2.

Aplicación

Anti-Peroxiredoxin-2 antibody is an antibody against Peroxiredoxin-2 for use in western blotting & ICC.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Peroxiredoxin-2 in 10 µg of human brain and rat hippocampus tissue lysate.

Immunocytochemistry Analysis: A representative lot detected Peroxiredoxin-2 in COS cells (Prof. Mustapha Oulad, IGBMC, France.).

Calidad

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Peroxiredoxin-2 in 10 µg of mouse brain tissue lysate.

Descripción de destino

~22 kDa observed

Forma física

Rabbit polyclonal serum without preservatives.

Unpurified

Almacenamiento y estabilidad

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable