ABC844

Anti-IEX1 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Radiation-inducible immediate-early gene IEX-1, Differentiation-dependent gene 2 protein, Protein DIF-2, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, Protein PRG1, IEX1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human
• técnicas: immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• Nº de acceso UniProt: P46695
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... IER3(8870)

Descripción

Descripción general

Radiation-inducible immediate-early gene IEX-1, also known as Differentiation-dependent gene 2 protein (DIF-2) or PACAP-responsive gene 1 protein (Protein PRG1), and encoded by the gene name IER3 or DIF2 or IEX1 or PRG1, is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-α. IEX1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. IEX1 plays an important role in the regulation of cellular growth, cell death and oncogenesis and is precisely regulated by multiple transcription factors such as p53, NF-κB/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX1 in cells under a variety of stress conditions. IEX1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX1 expression is associated with decreases in both apoptosis and cell cycle progression.

Inmunógeno

Epitope: Center region

KLH-conjugated synthetic peptide corresponding to the center region of human IEX1.

Aplicación

Anti-IEX1 Antibody is an antibody against IEX1 for use in western blotting, IHC & immunofluorescence.

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected IEX1 in human liver tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected IEX1 in human brain cells.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Calidad

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 4 μg/mL of this antibody detected IEX1 in human brain tissue lysate.

Descripción de destino

~16 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Forma física

Affinity

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable