ABC156

Anti-BAG family molecular chaperone regulator 3 (BAG3) Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human
• reactividad de especies (predicha por homología): rhesus macaque (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology), canine (based on 100% sequence homology)
• técnicas: immunohistochemistry: suitable (paraffin); western blot: suitable
• Nº de acceso NCBI: NP_004272
• Nº de acceso UniProt: O95817
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... BAG3(9531)

Descripción

Descripción general

Bcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH.

Inmunógeno

KLH-conjugated linear peptide corresponding to human BAG3.

Aplicación

Detect BAG family molecular chaperone regulator 3 (BAG3) using this Anti-BAG family molecular chaperone regulator 3 (BAG3) Antibody validated for use in Western Blotting, IHC(P).

Immunohistochemistry Analysis: A 1:500-1:1,000 dilution from a representative lot detected BAG3 in human cardiac and renal tissues.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Calidad

Evaluated by Western Blot in DU145 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected BAG3 in 10 µg of DU145 cell lysate.

Descripción de destino

~74/40 kDa observed. An uncharacterized band may appear at ~65 kDa in some lysates.

Forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
DU145 cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable