AB5930

Anti-Potassium Channel ERG1 Antibody, CT

Chemicon^®, from rabbit

• Sinónimos: Ether-a-go-go-related Gene Product, HERG1, MERG1, RERG1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human, mouse, rat
• fabricante / nombre comercial: Chemicon^®
• técnicas: immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• Nº de acceso NCBI: NM_000238.2; NM_172056.1; NM_172057.1
• Nº de acceso UniProt: Q12809
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... KCNH2(3757)

Descripción

Descripción general

ERG1 encodes the pore forming alpha subunit of the voltage-gated channels that conduct the rapid delayed rectifier potassium current, which leads to termination of the cardiac ventricular action potential. A large number of commercially available therapeutic agents (antiarrhythmics, antihistamines, antibiotics and antidepressants) have been shown to preferentially block ERG1 and cause a disorder of cardiac action potential depolarization that predisposes affected individuals to ventricular arrhythmia and sudden death.

Especificidad

ERG1 protein. By western blot, antibody recognizes bands at 175 and 205 kDa (glycosylated) or 135 and 165 kDa (deglycosylated).

Inmunógeno

Epitope: C-terminus

Synthetic peptide corresponding to the C-terminus of ERG1 (aa 1145-1159 of HERG1).

Aplicación

Anti-Potassium Channel ERG1 Antibody, C-terminus detects level of Potassium Channel ERG1 & has been published & validated for use in IC, IH, IP & WB.

Immunoblotting: 5 μg/mL

Immunocytochemistry

Immunohistochemistry on 4% paraformaldehyde fixed tissues.

Immunoprecipitation

Optimal working dilutions must be determined by end user.

Research Category
Neuroscience

Research Sub Category
Ion Channels & Transporters

Forma física

Liquid in PBS with 0.1% sodium azide.

Almacenamiento y estabilidad

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles

Nota de análisis

Control
Positive control tissue: Heart

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable